bis(hydroxymethyl)phenylphosphine-borane

Base Information

• Chemical Name: bis(hydroxymethyl)phenylphosphine-borane
• CAS No.: 869707-38-0
• Molecular Formula: C₈H₁₄BO₂P
• Molecular Weight: 183.983
• Mol file: 869707-38-0.mol

Synonyms:bis(hydroxymethyl)phenylphosphine-borane

Chemical Property of bis(hydroxymethyl)phenylphosphine-borane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of bis(hydroxymethyl)phenylphosphine-borane

There total 2 articles about bis(hydroxymethyl)phenylphosphine-borane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + phenylphosphane (638-21-1) → bis(hydroxymethyl)phenylphosphine-borane (869707-38-0)

Guidance literature:

formaldehyd; phenylphosphane; Heating;

With dimethylsulfide borane complex; In tetrahydrofuran; at 20 ℃; for 3h;

DOI:10.1021/ol0519893

Reference yield: 36.0%

bis(acetyloxymethyl)phenylphosphine-borane (869707-40-4) → bis(hydroxymethyl)phenylphosphine-borane (869707-38-0) + (R)-acetyloxymethyl(hydroxymethyl)phenylphosphine-borane + (S)-acetyloxymethyl(hydroxymethyl)phenylphosphine-borane

Guidance literature:

With Candida antarctica lipase B; phosphate buffer; In tetrahydrofuran; di-isopropyl ether; at 20 ℃; for 97h; pH=7;

DOI:10.1021/ol0519893

Reference yield: 32.0%

bis(hydroxymethyl)phenylphosphine-borane (869707-38-0) + vinyl acetate (108-05-4,9003-20-7) → (R)-acetyloxymethyl(hydroxymethyl)phenylphosphine-borane + (S)-acetyloxymethyl(hydroxymethyl)phenylphosphine-borane + bis(acetyloxymethyl)phenylphosphine-borane (869707-40-4)

Guidance literature:

With Candida antarctica lipase B; at 20 ℃; for 7h; Title compound not separated from byproducts;

DOI:10.1021/ol0519893

upstream raw materials:

bis(acetyloxymethyl)phenylphosphine-borane

formaldehyd

phenylphosphane

Downstream raw materials:

bis(acetyloxymethyl)phenylphosphine-borane