2-(3-(3-(3,4-dimethoxyphenyl)-1-((S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxamido)propyl)phenoxy)acetic acid

Base Information

• Chemical Name: 2-(3-(3-(3,4-dimethoxyphenyl)-1-((S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxamido)propyl)phenoxy)acetic acid
• CAS No.: 1374118-90-7
• Molecular Formula: C₃₂H₄₂N₂O₈
• Molecular Weight: 582.694
• Mol file: 1374118-90-7.mol

Synonyms:2-(3-(3-(3,4-dimethoxyphenyl)-1-((S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxamido)propyl)phenoxy)acetic acid

Chemical Property of 2-(3-(3-(3,4-dimethoxyphenyl)-1-((S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxamido)propyl)phenoxy)acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3-(3-(3,4-dimethoxyphenyl)-1-((S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxamido)propyl)phenoxy)acetic acid

There total 6 articles about 2-(3-(3-(3,4-dimethoxyphenyl)-1-((S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxamido)propyl)phenoxy)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

C36H50N2O8 (1374119-30-8) → 2-(3-(3-(3,4-dimethoxyphenyl)-1-((S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxamido)propyl)phenoxy)acetic acid (1374118-90-7)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 6h;

DOI:10.1021/jm201746x

Reference yield:

ethyl (2S)-1-(1,2-dioxo-3,3-dimethylpentyl)-2-piperidinecarboxylate (152754-33-1) → 2-(3-(3-(3,4-dimethoxyphenyl)-1-((S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxamido)propyl)phenoxy)acetic acid (1374118-90-7)

Guidance literature:

Multi-step reaction with 3 steps

1: lithium hydroxide

2: dmap; dicyclohexyl-carbodiimide / dichloromethane / 12 h / 20 °C

3: trifluoroacetic acid / dichloromethane / 6 h / 20 °C

With dmap; dicyclohexyl-carbodiimide; trifluoroacetic acid; lithium hydroxide; In dichloromethane;

DOI:10.1021/jm201746x

Reference yield:

2[[3-(3,4-dimethyoxyphenyl)-1-oxopropyl]phenoxy]acetic acid 1,1-dimethylester (178445-86-8) → 2-(3-(3-(3,4-dimethoxyphenyl)-1-((S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxamido)propyl)phenoxy)acetic acid (1374118-90-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium tetrahydroborate

2.1: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide; toluene

2.2: 750.08 Torr

3.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 12 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 6 h / 20 °C

With dmap; sodium tetrahydroborate; diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; toluene;

DOI:10.1021/jm201746x

upstream raw materials:

tert-butyl 2-(3-(3-(3,4-dimethoxyphenyl)-1-hydroxypropyl)phenoxy)acetate

(S)-methyl 1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate

C₃₆H₅₀N₂O₈

ethyl (2S)-1-(1,2-dioxo-3,3-dimethylpentyl)-2-piperidinecarboxylate