3-{4-[(3-methoxycarbonylphenylcarbamoyl)-methoxy]-phenyl}-[4-(4-trifluoromethylbenzyl)piperazin-1-yl]-adamantan-1-ylmethanone

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Chemical Name:3-{4-[(3-methoxycarbonylphenylcarbamoyl)-methoxy]-phenyl}-[4-(4-trifluoromethylbenzyl)piperazin-1-yl]-adamantan-1-ylmethanone
CAS No.:1192322-79-4
Molecular Formula:C₃₉H₄₂F₃N₃O₅
Molecular Weight:689.775
Hs Code.:

Synonyms:3-{4-[(3-methoxycarbonylphenylcarbamoyl)-methoxy]-phenyl}-[4-(4-trifluoromethylbenzyl)piperazin-1-yl]-adamantan-1-ylmethanone

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Chemical Property of 3-{4-[(3-methoxycarbonylphenylcarbamoyl)-methoxy]-phenyl}-[4-(4-trifluoromethylbenzyl)piperazin-1-yl]-adamantan-1-ylmethanone

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Technology Process of 3-{4-[(3-methoxycarbonylphenylcarbamoyl)-methoxy]-phenyl}-[4-(4-trifluoromethylbenzyl)piperazin-1-yl]-adamantan-1-ylmethanone

There total 3 articles about 3-{4-[(3-methoxycarbonylphenylcarbamoyl)-methoxy]-phenyl}-[4-(4-trifluoromethylbenzyl)piperazin-1-yl]-adamantan-1-ylmethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 1192322-55-6
3-{4-[(3-methoxycarbonyl-phenyl-carbamoyl)-methoxy]-phenyl}-adamantane-1-carboxylic acid

: 107890-32-4
1-(4-trifluoromethylbenzyl)piperazine

: 1192322-79-4
3-{4-[(3-methoxycarbonylphenylcarbamoyl)-methoxy]-phenyl}-[4-(4-trifluoromethylbenzyl)piperazin-1-yl]-adamantan-1-ylmethanone

Guidance literature:: C₂₇H₂₉NO₆; With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In acetonitrile; at 20 ℃; for 0.5h;

1-(4-trifluoromethylbenzyl)piperazine; In acetonitrile;
DOI:10.2174/1573406412666151109113007

Reference yield:

: 1192322-53-4
3-(4-[(3-methoxycarbonylphenylcarbamoyl)methoxy]phenyl)adamantane-1-carboxylic acid benzylester

: 1192322-79-4
3-{4-[(3-methoxycarbonylphenylcarbamoyl)-methoxy]-phenyl}-[4-(4-trifluoromethylbenzyl)piperazin-1-yl]-adamantan-1-ylmethanone

Guidance literature:: Multi-step reaction with 2 steps

1: palladium on activated charcoal

2: triethylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / acetonitrile / 0.5 h / 20 °C

With palladium on activated charcoal; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In acetonitrile;
DOI:10.2174/1573406412666151109113007

Reference yield:

: 4518-10-9
Methyl 3-aminobenzoate

: 1192322-79-4
3-{4-[(3-methoxycarbonylphenylcarbamoyl)-methoxy]-phenyl}-[4-(4-trifluoromethylbenzyl)piperazin-1-yl]-adamantan-1-ylmethanone

Guidance literature:: Multi-step reaction with 3 steps

1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; dmap

2: palladium on activated charcoal

3: triethylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / acetonitrile / 0.5 h / 20 °C

With dmap; palladium on activated charcoal; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In acetonitrile;
DOI:10.2174/1573406412666151109113007