tert-butyl (3R,αS)-3-(N-benzyl-N-α-methyl-4-methoxybenzylamino)pent-4-enoate

Base Information

Chemical Name:tert-butyl (3R,αS)-3-(N-benzyl-N-α-methyl-4-methoxybenzylamino)pent-4-enoate
CAS No.:445018-43-9
Molecular Formula:C₂₅H₃₃NO₃
Molecular Weight:395.542
Hs Code.:

Synonyms:tert-butyl (3R,αS)-3-(N-benzyl-N-α-methyl-4-methoxybenzylamino)pent-4-enoate

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Chemical Property of tert-butyl (3R,αS)-3-(N-benzyl-N-α-methyl-4-methoxybenzylamino)pent-4-enoate

Chemical Property:

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Technology Process of tert-butyl (3R,αS)-3-(N-benzyl-N-α-methyl-4-methoxybenzylamino)pent-4-enoate

There total 4 articles about tert-butyl (3R,αS)-3-(N-benzyl-N-α-methyl-4-methoxybenzylamino)pent-4-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 16809-92-0
tert-butyl (2E)-penta-2,4-dienoate

: 120343-46-6
(S)-N-benzyl-N-(α-methyl-p-methoxybenzyl)amine

: 445018-43-9
tert-butyl (3R,αS)-3-(N-benzyl-N-α-methyl-4-methoxybenzylamino)pent-4-enoate

Guidance literature:: (S)-N-benzyl-N-(α-methyl-p-methoxybenzyl)amine; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.5h;

tert-butyl (2E)-penta-2,4-dienoate; In tetrahydrofuran; at -78 ℃; for 2h; Further stages.;
DOI:10.1039/b106389h

Reference yield:

: 6298-96-0,22038-86-4,35600-82-9,41851-59-6
(S)-1-(4-methoxyphenyl)ethylamine

: 445018-43-9
tert-butyl (3R,αS)-3-(N-benzyl-N-α-methyl-4-methoxybenzylamino)pent-4-enoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethanol / 2 h / Heating

2.1: NaBH₄ / ethanol / 0 - 20 °C

3.1: BuLi / tetrahydrofuran / 0.5 h / -78 °C

3.2: 81 percent / tetrahydrofuran / 2 h / -78 °C

With sodium tetrahydroborate; n-butyllithium; In tetrahydrofuran; ethanol;
DOI:10.1039/b106389h

Reference yield:

: 100-52-7
benzaldehyde

: 445018-43-9
tert-butyl (3R,αS)-3-(N-benzyl-N-α-methyl-4-methoxybenzylamino)pent-4-enoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethanol / 2 h / Heating

2.1: NaBH₄ / ethanol / 0 - 20 °C

3.1: BuLi / tetrahydrofuran / 0.5 h / -78 °C

3.2: 81 percent / tetrahydrofuran / 2 h / -78 °C

With sodium tetrahydroborate; n-butyllithium; In tetrahydrofuran; ethanol;
DOI:10.1039/b106389h