4-(6-chloro-3-methyl-2-(4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroquinolin-4-yl)-2-methoxyphenol

Base Information

Chemical Name:4-(6-chloro-3-methyl-2-(4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroquinolin-4-yl)-2-methoxyphenol
CAS No.:1381866-39-2
Molecular Formula:C₂₄H₂₁ClF₃NO₂
Molecular Weight:447.884
Hs Code.:

Synonyms:4-(6-chloro-3-methyl-2-(4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroquinolin-4-yl)-2-methoxyphenol

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Chemical Property of 4-(6-chloro-3-methyl-2-(4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroquinolin-4-yl)-2-methoxyphenol

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Technology Process of 4-(6-chloro-3-methyl-2-(4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroquinolin-4-yl)-2-methoxyphenol

There total 3 articles about 4-(6-chloro-3-methyl-2-(4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroquinolin-4-yl)-2-methoxyphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5932-68-3
(E)-2-methoxy-4-(1-propenyl)phenol

: 79128-84-0
N-(4-chlorophenyl)-1-(4-(trifluoromethyl)phenyl)methanimine

: 1381866-39-2
4-(6-chloro-3-methyl-2-(4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroquinolin-4-yl)-2-methoxyphenol

Guidance literature:: With (R)-3,3'-bis(2,4,6-triisopropylphenyl)binol phosphoric acid; In 1,2-dichloro-ethane; at 50 ℃; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1021/ol301251h

Reference yield:

: 5912-86-7
cis-isoeugenol

: 1381866-39-2
4-(6-chloro-3-methyl-2-(4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroquinolin-4-yl)-2-methoxyphenol

Guidance literature:: Multi-step reaction with 2 steps

1: phosphoric acid / 1,2-dichloro-ethane / 48 h / 50 °C / Inert atmosphere

2: (R)-3,3'-bis(2,4,6-triisopropylphenyl)binol phosphoric acid / 1,2-dichloro-ethane / 50 °C / Inert atmosphere

With (R)-3,3'-bis(2,4,6-triisopropylphenyl)binol phosphoric acid; phosphoric acid; In 1,2-dichloro-ethane; 2: Aza-Diels-Alder reaction;
DOI:10.1021/ol301251h

Reference yield:

: 455-19-6
4-Trifluoromethylbenzaldehyde

: 106-47-8
4-chloro-aniline

: 1381866-39-2
4-(6-chloro-3-methyl-2-(4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroquinolin-4-yl)-2-methoxyphenol

Guidance literature:: Multi-step reaction with 2 steps

1: (R)-3,3'-bis(2,4,6-triisopropylphenyl)binol phosphoric acid / 1,2-dichloro-ethane / 1 h / 20 °C / Inert atmosphere

2: (R)-3,3'-bis(2,4,6-triisopropylphenyl)binol phosphoric acid / 1,2-dichloro-ethane / 50 °C / Inert atmosphere

With (R)-3,3'-bis(2,4,6-triisopropylphenyl)binol phosphoric acid; In 1,2-dichloro-ethane; 2: Aza-Diels-Alder reaction;
DOI:10.1021/ol301251h