6-chloro-2-(4-fluorophenyl)benzo[d]oxazole

Base Information

• Chemical Name: 6-chloro-2-(4-fluorophenyl)benzo[d]oxazole
• CAS No.: 1315571-17-5
• Molecular Formula: C₁₃H₇ClFNO
• Molecular Weight: 247.656
• Mol file: 1315571-17-5.mol

Synonyms:6-chloro-2-(4-fluorophenyl)benzo[d]oxazole

Chemical Property of 6-chloro-2-(4-fluorophenyl)benzo[d]oxazole

Chemical Property:

Purity/Quality:

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Technology Process of 6-chloro-2-(4-fluorophenyl)benzo[d]oxazole

There total 6 articles about 6-chloro-2-(4-fluorophenyl)benzo[d]oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-amino-5-chlorophenol (28443-50-7) + 9-methyl-9H-fluorene-9-carbonyl chloride (82102-37-2) + 1-Bromo-4-fluorobenzene (460-00-4) → 6-chloro-2-(4-fluorophenyl)benzo[d]oxazole (1315571-17-5)

Guidance literature:

2-amino-5-chlorophenol; 1-Bromo-4-fluorobenzene; With dichloro(1,5-cyclooctadiene)palladium(II); 1,8-diazabicyclo[5.4.0]undec-7-ene; tri tert-butylphosphoniumtetrafluoroborate; In 1,4-dioxane;

9-methyl-9H-fluorene-9-carbonyl chloride; With dichloro(1,5-cyclooctadiene)palladium(II); N-Methyldicyclohexylamine; tri tert-butylphosphoniumtetrafluoroborate; In 1,4-dioxane; at 80 ℃; for 15h; Inert atmosphere;

With methanesulfonic acid; In 1,4-dioxane; at 100 ℃; for 4h; Inert atmosphere;

DOI:10.1021/acs.orglett.5b00642

Reference yield: 95.0%

4-fluorobenzaldehyde (459-57-4) + 2-amino-5-chlorophenol (28443-50-7) → 6-chloro-2-(4-fluorophenyl)benzo[d]oxazole (1315571-17-5)

Guidance literature:

With copper(II) ferrite; oxygen; In toluene; at 110 ℃; for 24h; Schlenk technique; Sealed tube; Green chemistry;

DOI:10.1039/c4ra00559g

Reference yield: 86.0%

N-(2,4-Dichloro-phenyl)-4-fluoro-benzamide (101398-11-2) → 6-chloro-2-(4-fluorophenyl)benzo[d]oxazole (1315571-17-5)

Guidance literature:

With potassium phosphate; copper(l) iodide; 2-methoxybenzoic acid methyl ester; In N,N-dimethyl-formamide; at 135 ℃; for 12h;

DOI:10.1039/c4ob02068e

upstream raw materials:

4-Fluorobenzoic acid

2-amino-phenol

2-(4-fluorophenyl)benzoxazole

4-fluorobenzaldehyde