2,2,2-Trifluoro-N-methyl-N-{2-[1-(3-methyl-pyridin-2-yl)-1H-imidazol-2-ylsulfanylmethyl]-phenyl}-acetamide

Base Information

Chemical Name:2,2,2-Trifluoro-N-methyl-N-{2-[1-(3-methyl-pyridin-2-yl)-1H-imidazol-2-ylsulfanylmethyl]-phenyl}-acetamide
CAS No.:173472-08-7
Molecular Formula:C₁₉H₁₇F₃N₄OS
Molecular Weight:406.431
Hs Code.:

Synonyms:2,2,2-Trifluoro-N-methyl-N-{2-[1-(3-methyl-pyridin-2-yl)-1H-imidazol-2-ylsulfanylmethyl]-phenyl}-acetamide

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Chemical Property of 2,2,2-Trifluoro-N-methyl-N-{2-[1-(3-methyl-pyridin-2-yl)-1H-imidazol-2-ylsulfanylmethyl]-phenyl}-acetamide

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Technology Process of 2,2,2-Trifluoro-N-methyl-N-{2-[1-(3-methyl-pyridin-2-yl)-1H-imidazol-2-ylsulfanylmethyl]-phenyl}-acetamide

There total 8 articles about 2,2,2-Trifluoro-N-methyl-N-{2-[1-(3-methyl-pyridin-2-yl)-1H-imidazol-2-ylsulfanylmethyl]-phenyl}-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 173472-07-6
2-<<2-(trifluoroacetoamido)benzyl>thio>-1-<2-(3-methylpyridyl)>imidazole

: 74-88-4
methyl iodide

: 173472-08-7
2,2,2-Trifluoro-N-methyl-N-{2-[1-(3-methyl-pyridin-2-yl)-1H-imidazol-2-ylsulfanylmethyl]-phenyl}-acetamide

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; for 3h;
DOI:10.1021/jm950610n

Reference yield:

: 1603-40-3
3-methylpyridin-2-ylamine

: 173472-08-7
2,2,2-Trifluoro-N-methyl-N-{2-[1-(3-methyl-pyridin-2-yl)-1H-imidazol-2-ylsulfanylmethyl]-phenyl}-acetamide

Guidance literature:: Multi-step reaction with 6 steps

1: 67 percent / toluene / 18 h / Heating

2: 63 percent / AcOH, HCl / 18 h / Heating

3: 75 percent / NaH / dimethylformamide / 3 h / 0 °C

4: 83 percent / NH₂NH₂ hydrate / ethanol / 2 h / Ambient temperature

5: 86 percent / pyridine / 0 °C

6: 87 percent / NaH / dimethylformamide / 3 h

With pyridine; hydrogenchloride; sodium hydride; hydrazine hydrate; acetic acid; In ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm950610n

Reference yield:

: 57365-06-7
2-<2-(bromomethyl)phenyl>-1H-isoindole-1,3(2H)-dione

: 173472-08-7
2,2,2-Trifluoro-N-methyl-N-{2-[1-(3-methyl-pyridin-2-yl)-1H-imidazol-2-ylsulfanylmethyl]-phenyl}-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / NaH / dimethylformamide / 3 h / 0 °C

2: 83 percent / NH₂NH₂ hydrate / ethanol / 2 h / Ambient temperature

3: 86 percent / pyridine / 0 °C

4: 87 percent / NaH / dimethylformamide / 3 h

With pyridine; sodium hydride; hydrazine hydrate; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm950610n