4-[3-(3,4-dimethoxybenzyl)-6-hydroxy-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl]piperidine-1-carbaldehyde

Base Information

Chemical Name:4-[3-(3,4-dimethoxybenzyl)-6-hydroxy-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl]piperidine-1-carbaldehyde
CAS No.:1140589-65-6
Molecular Formula:C₂₃H₂₅N₃O₆
Molecular Weight:439.468
Hs Code.:

Synonyms:4-[3-(3,4-dimethoxybenzyl)-6-hydroxy-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl]piperidine-1-carbaldehyde

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Chemical Property of 4-[3-(3,4-dimethoxybenzyl)-6-hydroxy-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl]piperidine-1-carbaldehyde

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Technology Process of 4-[3-(3,4-dimethoxybenzyl)-6-hydroxy-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl]piperidine-1-carbaldehyde

There total 11 articles about 4-[3-(3,4-dimethoxybenzyl)-6-hydroxy-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl]piperidine-1-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1140590-69-7
4-[6-(benzyloxy)-3-(3,4-dimethoxybenzyl)-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl]piperidine-1-carbaldehyde

: 1140589-65-6
4-[3-(3,4-dimethoxybenzyl)-6-hydroxy-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl]piperidine-1-carbaldehyde

Guidance literature:: With ammonium formate; palladium 10% on activated carbon; In ethanol; at 80 ℃; for 2h; Microwave irradiation;

Reference yield:

: 1140590-83-5
1,1-dimethylethyl 4-[6-(benzyloxy)-3-(3,4-dimethoxybenzyl)-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl]piperidine-1-carboxylate

: 1140589-65-6
4-[3-(3,4-dimethoxybenzyl)-6-hydroxy-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl]piperidine-1-carbaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

2: acetonitrile / 1 h / 140 °C / Microwave irradiation

3: ammonium formate / palladium 10% on activated carbon / ethanol / 2 h / 80 °C / Microwave irradiation

With ammonium formate; trifluoroacetic acid; palladium 10% on activated carbon; In ethanol; dichloromethane; acetonitrile;

Reference yield:

: 1140590-82-4
1,1-dimethylethyl 4-[{4-(benzyloxy)-2-[(3,4-dimethoxybenzyl)carbamoyl]phenyl}(isobutoxycarbonyl)amino]piperidine-1-carboxylate

: 1140589-65-6
4-[3-(3,4-dimethoxybenzyl)-6-hydroxy-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl]piperidine-1-carbaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide; water / dichloromethane / 110 °C / Microwave irradiation

2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

3: acetonitrile / 1 h / 140 °C / Microwave irradiation

4: ammonium formate / palladium 10% on activated carbon / ethanol / 2 h / 80 °C / Microwave irradiation

With water; ammonium formate; trifluoroacetic acid; sodium hydroxide; palladium 10% on activated carbon; In ethanol; dichloromethane; acetonitrile;