(E)-methyl α-(3-formyl-1H-indol-2-yl)-β-[2-(tert-butoxycarbonyl)aminophenyl]acrylate

Base Information

• Chemical Name: (E)-methyl α-(3-formyl-1H-indol-2-yl)-β-[2-(tert-butoxycarbonyl)aminophenyl]acrylate
• CAS No.: 1465030-47-0
• Molecular Formula: C₂₄H₂₄N₂O₅
• Molecular Weight: 420.465
• Mol file: 1465030-47-0.mol

Synonyms:(E)-methyl α-(3-formyl-1H-indol-2-yl)-β-[2-(tert-butoxycarbonyl)aminophenyl]acrylate

Chemical Property of (E)-methyl α-(3-formyl-1H-indol-2-yl)-β-[2-(tert-butoxycarbonyl)aminophenyl]acrylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of (E)-methyl α-(3-formyl-1H-indol-2-yl)-β-[2-(tert-butoxycarbonyl)aminophenyl]acrylate

There total 1 articles about (E)-methyl α-(3-formyl-1H-indol-2-yl)-β-[2-(tert-butoxycarbonyl)aminophenyl]acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

methyl 2-(3-formyl-1H-indol-2-yl)acetate (64951-03-7) + tert-butyl (2-formylphenyl)carbamate (74965-38-1) → (E)-methyl α-(3-formyl-1H-indol-2-yl)-β-[2-(tert-butoxycarbonyl)aminophenyl]acrylate (1465030-47-0)

Guidance literature:

With L-proline; In dimethyl sulfoxide; at 20 ℃; for 60h; stereoselective reaction; Inert atmosphere;

DOI:10.1039/c3ob41573b

Reference yield: 86.0%

(E)-methyl α-(3-formyl-1H-indol-2-yl)-β-[2-(tert-butoxycarbonyl)aminophenyl]acrylate (1465030-47-0) → methyl 3-[2-(tert-butoxycarbonyl)aminophenyl]-5H-pyrido[4,3-b]indole-4-carboxylate (1465031-18-8)

Guidance literature:

With ammonium acetate; In dimethyl sulfoxide; at 20 ℃;

DOI:10.1039/c3ob41573b

upstream raw materials:

methyl 2-(3-formyl-1H-indol-2-yl)acetate

tert-butyl (2-formylphenyl)carbamate

Downstream raw materials:

methyl 3-[2-(tert-butoxycarbonyl)aminophenyl]-5H-pyrido[4,3-b]indole-4-carboxylate