2'-O-phenoxycarbonyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

Base Information

Chemical Name:2'-O-phenoxycarbonyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine
CAS No.:1192821-14-9
Molecular Formula:C₂₈H₄₂N₂O₉Si₂
Molecular Weight:606.82
Hs Code.:

Synonyms:2'-O-phenoxycarbonyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

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Chemical Property of 2'-O-phenoxycarbonyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

Chemical Property:

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Technology Process of 2'-O-phenoxycarbonyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

There total 1 articles about 2'-O-phenoxycarbonyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1885-14-9
phenyl chloroformate

: 69304-38-7
3',5'-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

: 1192821-14-9
2'-O-phenoxycarbonyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

Guidance literature:: With pyridine; In toluene; at 20 ℃; for 3h;
DOI:10.1016/j.bmc.2009.08.053

Reference yield:

: 1192821-14-9
2'-O-phenoxycarbonyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

: 1366234-57-2
C₃₇H₃₉F₃N₄O₁₀

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / 3 h / 0 °C

2.1: triethylamine / ethanol / 20 °C

3.1: triethylamine tris(hydrogen fluoride); triethylamine / tetrahydrofuran / 3 h / 20 °C

3.2: 20 °C

4.1: pyridine / 8 h / 20 °C

With pyridine; triethylamine tris(hydrogen fluoride); triethylamine; In tetrahydrofuran; ethanol;
DOI:10.1016/j.bmcl.2012.02.012

Reference yield:

: 1192821-14-9
2'-O-phenoxycarbonyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

: 1366234-58-3
C₄₆H₅₆F₃N₆O₁₁P

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine / 3 h / 0 °C

2.1: triethylamine / ethanol / 20 °C

3.1: triethylamine tris(hydrogen fluoride); triethylamine / tetrahydrofuran / 3 h / 20 °C

3.2: 20 °C

4.1: pyridine / 8 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

With pyridine; triethylamine tris(hydrogen fluoride); triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2012.02.012