(E)-1-(tert-Butoxycarbonylamino)-7-(1'-hydroxy-3'-phenylprop-2'-en-1'-yl)-1H-1,2,3-benzotriazole

Base Information

• Chemical Name: (E)-1-(tert-Butoxycarbonylamino)-7-(1'-hydroxy-3'-phenylprop-2'-en-1'-yl)-1H-1,2,3-benzotriazole
• CAS No.: 328575-23-1
• Molecular Formula: C₂₀H₂₂N₄O₃
• Molecular Weight: 366.42
• Mol file: 328575-23-1.mol

Synonyms:(E)-1-(tert-Butoxycarbonylamino)-7-(1'-hydroxy-3'-phenylprop-2'-en-1'-yl)-1H-1,2,3-benzotriazole

Chemical Property of (E)-1-(tert-Butoxycarbonylamino)-7-(1'-hydroxy-3'-phenylprop-2'-en-1'-yl)-1H-1,2,3-benzotriazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-1-(tert-Butoxycarbonylamino)-7-(1'-hydroxy-3'-phenylprop-2'-en-1'-yl)-1H-1,2,3-benzotriazole

There total 2 articles about (E)-1-(tert-Butoxycarbonylamino)-7-(1'-hydroxy-3'-phenylprop-2'-en-1'-yl)-1H-1,2,3-benzotriazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

(E)-3-phenylpropenal (14371-10-9) + 1-(tert-Butoxycarbonylamino)-1H-benzotriazole (181707-16-4) → (E)-1-(tert-Butoxycarbonylamino)-7-(1'-hydroxy-3'-phenylprop-2'-en-1'-yl)-1H-1,2,3-benzotriazole (328575-23-1)

Guidance literature:

1-(tert-Butoxycarbonylamino)-1H-benzotriazole; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

With cerium(III) chloride; In tetrahydrofuran; hexane; at -78 ℃; for 3h;

(E)-3-phenylpropenal; In tetrahydrofuran; hexane; at 20 ℃; for 16h; Further stages.;

DOI:10.1039/b005696k

Reference yield: 71.0%

(E)-3-phenylpropenal (14371-10-9) + C11H12N4O2(2-) → (E)-1-(tert-Butoxycarbonylamino)-7-(1'-hydroxy-3'-phenylprop-2'-en-1'-yl)-1H-1,2,3-benzotriazole (328575-23-1)

Guidance literature:

DOI:10.1016/S0040-4039(97)01064-2

Reference yield: 78.0%

acetic anhydride (108-24-7) + (E)-1-(tert-Butoxycarbonylamino)-7-(1'-hydroxy-3'-phenylprop-2'-en-1'-yl)-1H-1,2,3-benzotriazole (328575-23-1) → (E)-1-(tert-Butoxycarbonylacetamido)-7-(1'-acetyloxy-3'-phenylprop-2'-en-1'-yl)-1H-1,2,3-benzotriazole

Guidance literature:

With dmap; In dichloromethane;

DOI:10.1039/b005696k

upstream raw materials:

(E)-3-phenylpropenal

1-(tert-Butoxycarbonylamino)-1H-benzotriazole

Downstream raw materials:

(E)-1-(tert-Butoxycarbonylamino)-7-(3'-phenyl-1'-oxoprop-2'-en-1'-yl)benzotriazole