(E)-1-(tert-Butoxycarbonylamino)-7-(3'-phenyl-1'-oxoprop-2'-en-1'-yl)benzotriazole

Base Information

Chemical Name:(E)-1-(tert-Butoxycarbonylamino)-7-(3'-phenyl-1'-oxoprop-2'-en-1'-yl)benzotriazole
CAS No.:300549-87-5
Molecular Formula:C₂₀H₂₀N₄O₃
Molecular Weight:364.404
Hs Code.:

Synonyms:(E)-1-(tert-Butoxycarbonylamino)-7-(3'-phenyl-1'-oxoprop-2'-en-1'-yl)benzotriazole

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Chemical Property of (E)-1-(tert-Butoxycarbonylamino)-7-(3'-phenyl-1'-oxoprop-2'-en-1'-yl)benzotriazole

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Technology Process of (E)-1-(tert-Butoxycarbonylamino)-7-(3'-phenyl-1'-oxoprop-2'-en-1'-yl)benzotriazole

There total 7 articles about (E)-1-(tert-Butoxycarbonylamino)-7-(3'-phenyl-1'-oxoprop-2'-en-1'-yl)benzotriazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 4187-87-5
1-Phenyl-2-propyn-1-ol

: 181707-15-3
1-(tert-Butoxycarbonylamino)-7-iodobenzotriazole

: 1-(tert-Butoxycarbonylamino)-7-(3'-hydroxy-3'-phenylprop-1'-yn-1'-yl)benzotriazole

: 300549-87-5
(E)-1-(tert-Butoxycarbonylamino)-7-(3'-phenyl-1'-oxoprop-2'-en-1'-yl)benzotriazole

Guidance literature:: With copper(l) iodide; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; for 18h; Heating;
DOI:10.1039/b001834l

Reference yield:

: 328575-23-1
(E)-1-(tert-Butoxycarbonylamino)-7-(1'-hydroxy-3'-phenylprop-2'-en-1'-yl)-1H-1,2,3-benzotriazole

: 300549-87-5
(E)-1-(tert-Butoxycarbonylamino)-7-(3'-phenyl-1'-oxoprop-2'-en-1'-yl)benzotriazole

Guidance literature:: With manganese(IV) oxide; In dichloromethane; at 20 ℃; for 36h;
DOI:10.1039/b005696k

Reference yield:

: 95-14-7,27556-51-0
1,2,3-Benzotriazole

: 1-(tert-Butoxycarbonylamino)-7-(3'-hydroxy-3'-phenylprop-1'-yn-1'-yl)benzotriazole

: 300549-87-5
(E)-1-(tert-Butoxycarbonylamino)-7-(3'-phenyl-1'-oxoprop-2'-en-1'-yl)benzotriazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydroxide; hydroxylamine-O-sulfonic acid / N,N-dimethyl-formamide / 1 h / 20 °C

2.1: dmap / acetonitrile / 1 h

3.1: sodium hydroxide / methanol / 2 h / 50 °C

4.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -70 °C

4.2: CeCl₃; BuLi / 6; 13; 199 / 3 h / -70 - 0 °C

4.3: 1,2-diiodoethane / 6; 13; 199 / -78 - 20 °C

5.1: copper(l) iodide; triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 18 h / Heating

With dmap; potassium hydroxide; sodium hydroxide; copper(l) iodide; n-butyllithium; triethylamine; hydroxylamine-O-sulfonic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; hexane; N,N-dimethyl-formamide; acetonitrile; 1.1: Substitution / 2.1: Acylation / 3.1: Hydrolysis / 4.1: Metallation / 4.2: Transmetallation / 4.3: Substitution / 5.1: Substitution;
DOI:10.1039/b001834l