(1R,3R,4R)-3-methoxy-1-methoxycarbonyl-4-((trimethylsilylethoxy)methoxy)cyclohexane

Base Information

• Chemical Name: (1R,3R,4R)-3-methoxy-1-methoxycarbonyl-4-((trimethylsilylethoxy)methoxy)cyclohexane
• CAS No.: 158981-06-7
• Molecular Formula: C₁₅H₃₀O₅Si
• Molecular Weight: 318.486
• Mol file: 158981-06-7.mol

Synonyms:(1R,3R,4R)-3-methoxy-1-methoxycarbonyl-4-((trimethylsilylethoxy)methoxy)cyclohexane

Chemical Property of (1R,3R,4R)-3-methoxy-1-methoxycarbonyl-4-((trimethylsilylethoxy)methoxy)cyclohexane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,3R,4R)-3-methoxy-1-methoxycarbonyl-4-((trimethylsilylethoxy)methoxy)cyclohexane

There total 1 articles about (1R,3R,4R)-3-methoxy-1-methoxycarbonyl-4-((trimethylsilylethoxy)methoxy)cyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

(2-trimethylethylsilylethoxy)methyl chloride (76513-69-4) + (1R,3R,4R) methyl 4-hydroxy-3-methoxy-1-cyclohexanecarboxylate (128684-89-9) → (1R,3R,4R)-3-methoxy-1-methoxycarbonyl-4-((trimethylsilylethoxy)methoxy)cyclohexane (158981-06-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In chloroform; for 3h; Reflux; Inert atmosphere;

DOI:10.1016/j.tet.2009.06.030

Reference yield: 72.0%

(1R,3R,4R)-3-methoxy-1-methoxycarbonyl-4-((trimethylsilylethoxy)methoxy)cyclohexane (158981-06-7) → (1R,3R,4R)-3-methoxy-4-(trimethylsilylethoxy)methoxycyclohexanecarboxaldehyde (158981-07-8)

Guidance literature:

(1R,3R,4R)-3-methoxy-1-methoxycarbonyl-4-((trimethylsilylethoxy)methoxy)cyclohexane; With diisobutylaluminium hydride; In toluene; at -78 ℃; for 0.5h; Inert atmosphere;

With ammonium chloride; In water; toluene; at -78 ℃; Inert atmosphere;

DOI:10.1016/j.tet.2009.06.030

upstream raw materials:

(2-trimethylethylsilylethoxy)methyl chloride

(1R,3R,4R) methyl 4-hydroxy-3-methoxy-1-cyclohexanecarboxylate

Downstream raw materials:

(1R,3R,4R)-3-methoxy-4-(trimethylsilylethoxy)methoxycyclohexanecarboxaldehyde