(1R,3R,4R)-3-methoxy-4-(trimethylsilylethoxy)methoxycyclohexanecarboxaldehyde

Base Information

Chemical Name:(1R,3R,4R)-3-methoxy-4-(trimethylsilylethoxy)methoxycyclohexanecarboxaldehyde
CAS No.:158981-07-8
Molecular Formula:C₁₄H₂₈O₄Si
Molecular Weight:288.459
Hs Code.:

Synonyms:(1R,3R,4R)-3-methoxy-4-(trimethylsilylethoxy)methoxycyclohexanecarboxaldehyde

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Chemical Property of (1R,3R,4R)-3-methoxy-4-(trimethylsilylethoxy)methoxycyclohexanecarboxaldehyde

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Technology Process of (1R,3R,4R)-3-methoxy-4-(trimethylsilylethoxy)methoxycyclohexanecarboxaldehyde

There total 1 articles about (1R,3R,4R)-3-methoxy-4-(trimethylsilylethoxy)methoxycyclohexanecarboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 158981-06-7
(1R,3R,4R)-3-methoxy-1-methoxycarbonyl-4-((trimethylsilylethoxy)methoxy)cyclohexane

: 158981-07-8
(1R,3R,4R)-3-methoxy-4-(trimethylsilylethoxy)methoxycyclohexanecarboxaldehyde

Guidance literature:: (1R,3R,4R)-3-methoxy-1-methoxycarbonyl-4-((trimethylsilylethoxy)methoxy)cyclohexane; With diisobutylaluminium hydride; In toluene; at -78 ℃; for 0.5h; Inert atmosphere;

With ammonium chloride; In water; toluene; at -78 ℃; Inert atmosphere;
DOI:10.1016/j.tet.2009.06.030

Reference yield: 95.0%

: 158981-07-8
(1R,3R,4R)-3-methoxy-4-(trimethylsilylethoxy)methoxycyclohexanecarboxaldehyde

: 54356-04-6
[(1-ethoxycarbonyl)ethylidene]triphenylphosphorane

: C₁₉H₃₆O₅Si

Guidance literature:: In benzene; for 17h; diastereoselective reaction; Reflux; Inert atmosphere;
DOI:10.1016/j.tet.2009.06.030

Reference yield: 61.0%

: 158981-07-8
(1R,3R,4R)-3-methoxy-4-(trimethylsilylethoxy)methoxycyclohexanecarboxaldehyde

: 73198-78-4
α-(Trimethylsilyl)-tert-butylacetaldimine

: 1187542-30-8
C₁₆H₃₀O₄Si

Guidance literature:: α-(Trimethylsilyl)-tert-butylacetaldimine; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at 0 ℃; for 0.166667h; Inert atmosphere;

(1R,3R,4R)-3-methoxy-4-(trimethylsilylethoxy)methoxycyclohexanecarboxaldehyde; In tetrahydrofuran; hexane; at -78 - -20 ℃; for 3h; Inert atmosphere;

With oxalic acid; In tetrahydrofuran; hexane; water; at 20 ℃; for 0.75h; pH=4 - 4.5; diastereoselective reaction; Inert atmosphere;
DOI:10.1016/j.tet.2009.06.030