4-[(3,5-dimethyl-1H-pyrazol-1-yl)carbonyl]-1-(3-hydroxyphenyl)pyrrolidin-2-one

Base Information

• Chemical Name: 4-[(3,5-dimethyl-1H-pyrazol-1-yl)carbonyl]-1-(3-hydroxyphenyl)pyrrolidin-2-one
• CAS No.: 1427549-64-1
• Molecular Formula: C₁₆H₁₇N₃O₃
• Molecular Weight: 299.329

Synonyms:4-[(3,5-dimethyl-1H-pyrazol-1-yl)carbonyl]-1-(3-hydroxyphenyl)pyrrolidin-2-one

Chemical Property of 4-[(3,5-dimethyl-1H-pyrazol-1-yl)carbonyl]-1-(3-hydroxyphenyl)pyrrolidin-2-one

Chemical Property:

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Technology Process of 4-[(3,5-dimethyl-1H-pyrazol-1-yl)carbonyl]-1-(3-hydroxyphenyl)pyrrolidin-2-one

There total 2 articles about 4-[(3,5-dimethyl-1H-pyrazol-1-yl)carbonyl]-1-(3-hydroxyphenyl)pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(3-hydroxyphenyl)-2-oxopyrrolidine-4-carboxylic acid (91891-24-6) → 4-[(3,5-dimethyl-1H-pyrazol-1-yl)carbonyl]-1-(3-hydroxyphenyl)pyrrolidin-2-one (1427549-64-1)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid / 5 h / Reflux

2: hydrazine hydrate / isopropyl alcohol / 5 h / Reflux

3: hydrogenchloride / isopropyl alcohol / 6 h / Reflux

With hydrogenchloride; sulfuric acid; hydrazine hydrate; In isopropyl alcohol;

DOI:10.3390/molecules171214434

Reference yield:

N-(3-hydroxyphenyl)-2-oxopyrrolidine-4-carboxylic acid methyl ester (101626-19-1) → 4-[(3,5-dimethyl-1H-pyrazol-1-yl)carbonyl]-1-(3-hydroxyphenyl)pyrrolidin-2-one (1427549-64-1)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / isopropyl alcohol / 5 h / Reflux

2: hydrogenchloride / isopropyl alcohol / 6 h / Reflux

With hydrogenchloride; hydrazine hydrate; In isopropyl alcohol;

DOI:10.3390/molecules171214434

Reference yield: 72.0%

2,3-Dichloro-1,4-naphthoquinone (117-80-6) + 4-[(3,5-dimethyl-1H-pyrazol-1-yl)carbonyl]-1-(3-hydroxyphenyl)pyrrolidin-2-one (1427549-64-1) → 2-chloro-3-{3-[4-(3,5-dimethylpyrazole-1-carbonyl)-2-oxopyrrolidin-1-yl]phenoxy}-[1,4]naphthoquinone (1427549-82-3)

Guidance literature:

With sodium carbonate; In dimethyl sulfoxide; at 20 ℃; for 24h;

DOI:10.3390/molecules171214434

upstream raw materials:

N-(3-hydroxyphenyl)-2-oxopyrrolidine-4-carboxylic acid

N-(3-hydroxyphenyl)-2-oxopyrrolidine-4-carboxylic acid methyl ester

Downstream raw materials:

2-chloro-3-{3-[4-(3,5-dimethylpyrazole-1-carbonyl)-2-oxopyrrolidin-1-yl]phenoxy}-[1,4]naphthoquinone

2,3-bis(3-{4-[(3,5-dimethyl-1H-pyrazol-1-yl)carbonyl]-2-oxo-1-pyrrolidinyl}phenoxy)naphthoquinone

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