methyl (2s,3aR,5r,6aS)-5-cyano-5-(3,4-dimethoxyphenyl)octahydropentalene-2-carboxylate

Base Information

Chemical Name:methyl (2s,3aR,5r,6aS)-5-cyano-5-(3,4-dimethoxyphenyl)octahydropentalene-2-carboxylate
CAS No.:752259-60-2
Molecular Formula:C₁₉H₂₃NO₄
Molecular Weight:329.396
Hs Code.:

Synonyms:methyl (2s,3aR,5r,6aS)-5-cyano-5-(3,4-dimethoxyphenyl)octahydropentalene-2-carboxylate

Suppliers and Price of methyl (2s,3aR,5r,6aS)-5-cyano-5-(3,4-dimethoxyphenyl)octahydropentalene-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl (2s,3aR,5r,6aS)-5-cyano-5-(3,4-dimethoxyphenyl)octahydropentalene-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl (2s,3aR,5r,6aS)-5-cyano-5-(3,4-dimethoxyphenyl)octahydropentalene-2-carboxylate

There total 8 articles about methyl (2s,3aR,5r,6aS)-5-cyano-5-(3,4-dimethoxyphenyl)octahydropentalene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 752259-59-9
methyl (2s,3aR,5r,6aS)-5-cyano-5-(3-hydroxy-4-methoxyphenyl)octahydropentalene-2-carboxylate

: 74-88-4
methyl iodide

: 752259-60-2
methyl (2s,3aR,5r,6aS)-5-cyano-5-(3,4-dimethoxyphenyl)octahydropentalene-2-carboxylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 2h;
DOI:10.1016/j.ejmech.2004.02.010

Reference yield:

: 752259-56-6
(3aR,7aS)-2-[3-(benzyloxy)-4-methoxyphenyl]-2,3,3a,4,7,7a-hexahydro-1H-indene-2-carbonitrile

: 752259-60-2
methyl (2s,3aR,5r,6aS)-5-cyano-5-(3,4-dimethoxyphenyl)octahydropentalene-2-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: ozone / CH₂Cl₂ / 1 h / -78 °C

1.2: Ph₃P / CH₂Cl₂ / 1.5 h / -78 - 20 °C

2.1: NaClO₂; NaH₂PO₄; 2-methyl-2-butene / 2-methyl-propan-2-ol; H₂O / 3 h / 20 °C

3.1: diethyl ether / 0 °C

4.1: NaH / 1,2-dimethoxy-ethane / 1.5 h / Heating

4.2: 48 percent / NaCl; H₂O / dimethylsulfoxide / 1 h / 165 °C

5.1: LiHMDS / tetrahydrofuran / 0.75 h / -78 °C

5.2: tetrahydrofuran / 1 h / 0 °C

6.1: 8.82 g / PPh₃; Et₃N / Pd(OAc)2 / dimethylformamide / 20 °C

7.1: 26 percent / H₂ / Pd/C / methanol / 72 h / atmospheric pressure

8.1: 100 percent / K₂CO₃ / dimethylformamide / 2 h / 20 °C

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; hydrogen; sodium hydride; potassium carbonate; ozone; triethylamine; triphenylphosphine; lithium hexamethyldisilazane; palladium diacetate; palladium on activated charcoal; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol; 4.1: Dieckmann condensation;
DOI:10.1016/j.ejmech.2004.02.010

Reference yield:

: 752259-58-8
(2s,3aR,6aS)-2-[3-(benzyloxy)-4-methoxyphenyl]-5-oxooctahydropentalene-2-carbonitrile

: 752259-60-2
methyl (2s,3aR,5r,6aS)-5-cyano-5-(3,4-dimethoxyphenyl)octahydropentalene-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: LiHMDS / tetrahydrofuran / 0.75 h / -78 °C

1.2: tetrahydrofuran / 1 h / 0 °C

2.1: 8.82 g / PPh₃; Et₃N / Pd(OAc)2 / dimethylformamide / 20 °C

3.1: 26 percent / H₂ / Pd/C / methanol / 72 h / atmospheric pressure

4.1: 100 percent / K₂CO₃ / dimethylformamide / 2 h / 20 °C

With hydrogen; potassium carbonate; triethylamine; triphenylphosphine; lithium hexamethyldisilazane; palladium diacetate; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2004.02.010