Technology Process of 2,4-diamino-6-benzylbenzimidazole dihydrochloride
There total 9 articles about 2,4-diamino-6-benzylbenzimidazole dihydrochloride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride; hydrogen;
palladium on activated charcoal;
In
ethanol;
for 0.25h;
under 1551.4 Torr;
DOI:10.1021/jm00108a022
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 82.7 percent / NH3(gas) / dimethylsulfoxide
2: 79 percent / NH4SH / ethanol / 0.67 h
3: ethanol; H2O; acetonitrile / 48 h / Ambient temperature
4: 97 percent / TFA, Et3SiH / 96 h / Ambient temperature
5: 51 percent / H2, 12N HCl / 5percent Pd/C / ethanol / 0.25 h / 1551.4 Torr
With
hydrogenchloride; triethylsilane; ammonium sulfide; ammonia; hydrogen; trifluoroacetic acid;
palladium on activated charcoal;
In
ethanol; water; dimethyl sulfoxide; acetonitrile;
DOI:10.1021/jm00108a022
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 79 percent / NH4SH / ethanol / 0.67 h
2: ethanol; H2O; acetonitrile / 48 h / Ambient temperature
3: 97 percent / TFA, Et3SiH / 96 h / Ambient temperature
4: 51 percent / H2, 12N HCl / 5percent Pd/C / ethanol / 0.25 h / 1551.4 Torr
With
hydrogenchloride; triethylsilane; ammonium sulfide; hydrogen; trifluoroacetic acid;
palladium on activated charcoal;
In
ethanol; water; acetonitrile;
DOI:10.1021/jm00108a022
