40646-73-9

Upstream product

• 118-97-8 4-chloro-3,5-dinitrobenzoic acid 
• 42486-87-3 3,5-dinitro-4-chlorobenzenecarboxylic acid chloride 
• 71-43-2 benzene 
• 7446-70-0 aluminium trichloride 
• 10026-13-8 phosphorus pentachloride 
• 74-11-3 para-chlorobenzoic acid 

Downstream Products

• 39880-47-2 4-methoxy-3,5-dinitro-benzophenone 
• 861531-59-1 4-(2-mercapto-anilino)-3,5-dinitro-benzophenone 
• 133100-11-5 4-amino-3,5-dinitro-benzophenone 
• 861531-68-2 4-(2-hydroxy-anilino)-3,5-dinitro-benzophenone 
• 133100-15-9 2-amino-4-benzyl-6-nitroaniline 
• 133100-12-6 3,4-diamino-5-nitrobenzophenone 
• 133100-13-7 2-amino-6-benzyl-4-nitrobenzimidazole 
• 133100-14-8 4-benzyl-2,6-dinitroaniline 
• 133100-06-8 2,4-diamino-6-benzylbenzimidazole dihydrochloride 
• 750538-65-9 2-amino-6-benzoyl-4-nitrobenzimidazole 
• 876497-86-8 4'-methoxy-2,3',5'-trinitro-benzophenone 
• 872276-37-4 4-methoxy-3,5,3'-trinitro-benzophenone 

Relevant academic research and scientific papers

Receptor-based design of novel dihydrofolate reductase inhibitors: Benzimidazole and indole derivatives

Although many thousands of inhibitors of the enzyme dihydrofolate reductase (DHFR) have been synthesized, all of the very active compounds have been 2,4-diaminopyrimidines or very close analogues. This paper describes 2,4-diamino-6-benzylbenzimidazole (3b