4-[3-(2-cyclohexylethoxy)benzoyl]-N-[5-(hydroxymethyl)pyridin-3-yl]piperazine-1-carboxamide hydrochloride

Base Information

Chemical Name:4-[3-(2-cyclohexylethoxy)benzoyl]-N-[5-(hydroxymethyl)pyridin-3-yl]piperazine-1-carboxamide hydrochloride
CAS No.:1008764-15-5
Molecular Formula:C₂₆H₃₄N₄O₄*ClH
Molecular Weight:503.041
Hs Code.:

Synonyms:4-[3-(2-cyclohexylethoxy)benzoyl]-N-[5-(hydroxymethyl)pyridin-3-yl]piperazine-1-carboxamide hydrochloride

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Chemical Property of 4-[3-(2-cyclohexylethoxy)benzoyl]-N-[5-(hydroxymethyl)pyridin-3-yl]piperazine-1-carboxamide hydrochloride

Chemical Property:

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Technology Process of 4-[3-(2-cyclohexylethoxy)benzoyl]-N-[5-(hydroxymethyl)pyridin-3-yl]piperazine-1-carboxamide hydrochloride

There total 4 articles about 4-[3-(2-cyclohexylethoxy)benzoyl]-N-[5-(hydroxymethyl)pyridin-3-yl]piperazine-1-carboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1008775-31-2
4-[3-(2-cyclohexylethoxy)benzoyl]-N-[5-(hydroxymethyl)pyridin-3-yl]piperazine-1-carboxamide

: 1008764-15-5
4-[3-(2-cyclohexylethoxy)benzoyl]-N-[5-(hydroxymethyl)pyridin-3-yl]piperazine-1-carboxamide hydrochloride

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 20 ℃; for 3h;

Reference yield:

: 915391-81-0
5-(azidecarbonyl)nicotinic acid methyl ester

: 1008764-15-5
4-[3-(2-cyclohexylethoxy)benzoyl]-N-[5-(hydroxymethyl)pyridin-3-yl]piperazine-1-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene / 1 h / 120 °C

2.1: triethylamine / tetrahydrofuran; toluene / 10 h / 0 - 20 °C

3.1: lithium borohydride / tetrahydrofuran; ethanol

3.2: 0.17 h

4.1: hydrogenchloride / ethyl acetate / 3 h / 20 °C

With hydrogenchloride; lithium borohydride; triethylamine; In tetrahydrofuran; ethanol; ethyl acetate; toluene;

Reference yield:

: 1008775-30-1
methyl 5-[({4-[3-(2-cyclohexylethoxy)benzoyl]piperazin-1-yl}carbonyl)amino]nicotinate

: 1008764-15-5
4-[3-(2-cyclohexylethoxy)benzoyl]-N-[5-(hydroxymethyl)pyridin-3-yl]piperazine-1-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium borohydride / tetrahydrofuran; ethanol

1.2: 0.17 h

2.1: hydrogenchloride / ethyl acetate / 3 h / 20 °C

With hydrogenchloride; lithium borohydride; In tetrahydrofuran; ethanol; ethyl acetate;