methyl 5-[({4-[3-(2-cyclohexylethoxy)benzoyl]piperazin-1-yl}carbonyl)amino]nicotinate

Base Information

Chemical Name:methyl 5-[({4-[3-(2-cyclohexylethoxy)benzoyl]piperazin-1-yl}carbonyl)amino]nicotinate
CAS No.:1008775-30-1
Molecular Formula:C₂₇H₃₄N₄O₅
Molecular Weight:494.591
Hs Code.:

Synonyms:methyl 5-[({4-[3-(2-cyclohexylethoxy)benzoyl]piperazin-1-yl}carbonyl)amino]nicotinate

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Chemical Property of methyl 5-[({4-[3-(2-cyclohexylethoxy)benzoyl]piperazin-1-yl}carbonyl)amino]nicotinate

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Technology Process of methyl 5-[({4-[3-(2-cyclohexylethoxy)benzoyl]piperazin-1-yl}carbonyl)amino]nicotinate

There total 2 articles about methyl 5-[({4-[3-(2-cyclohexylethoxy)benzoyl]piperazin-1-yl}carbonyl)amino]nicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1008774-26-2
1-[3-(2-cyclohexylethoxy)benzoyl]piperazine hydrochloride

: C₈H₆N₂O₃

: 1008775-30-1
methyl 5-[({4-[3-(2-cyclohexylethoxy)benzoyl]piperazin-1-yl}carbonyl)amino]nicotinate

Guidance literature:: With triethylamine; In tetrahydrofuran; toluene; at 0 - 20 ℃; for 10h;

Reference yield:

: 915391-81-0
5-(azidecarbonyl)nicotinic acid methyl ester

: 1008775-30-1
methyl 5-[({4-[3-(2-cyclohexylethoxy)benzoyl]piperazin-1-yl}carbonyl)amino]nicotinate

Guidance literature:: Multi-step reaction with 2 steps

1: toluene / 1 h / 120 °C

2: triethylamine / tetrahydrofuran; toluene / 10 h / 0 - 20 °C

With triethylamine; In tetrahydrofuran; toluene;

Reference yield:

: 1008775-30-1
methyl 5-[({4-[3-(2-cyclohexylethoxy)benzoyl]piperazin-1-yl}carbonyl)amino]nicotinate

: 1008775-31-2
4-[3-(2-cyclohexylethoxy)benzoyl]-N-[5-(hydroxymethyl)pyridin-3-yl]piperazine-1-carboxamide

Guidance literature:: methyl 5-[({4-[3-(2-cyclohexylethoxy)benzoyl]piperazin-1-yl}carbonyl)amino]nicotinate; With lithium borohydride; In tetrahydrofuran; ethanol;

With water; sodium hydrogencarbonate; In tetrahydrofuran; ethanol; for 0.166667h;