3-(4-(N,N-bis-(2-chloroethyl)amino)phenoxysulfonyl-(2-(2-hydroxyethoxy)-4-chloro-6-methylpyridin-5-yl-methyl))methyl-2-nitrothiophene

Base Information

Chemical Name:3-(4-(N,N-bis-(2-chloroethyl)amino)phenoxysulfonyl-(2-(2-hydroxyethoxy)-4-chloro-6-methylpyridin-5-yl-methyl))methyl-2-nitrothiophene
CAS No.:1196072-22-6
Molecular Formula:C₂₄H₂₆Cl₃N₃O₇S₂
Molecular Weight:638.977
Hs Code.:

Synonyms:3-(4-(N,N-bis-(2-chloroethyl)amino)phenoxysulfonyl-(2-(2-hydroxyethoxy)-4-chloro-6-methylpyridin-5-yl-methyl))methyl-2-nitrothiophene

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Chemical Property of 3-(4-(N,N-bis-(2-chloroethyl)amino)phenoxysulfonyl-(2-(2-hydroxyethoxy)-4-chloro-6-methylpyridin-5-yl-methyl))methyl-2-nitrothiophene

Chemical Property:

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Technology Process of 3-(4-(N,N-bis-(2-chloroethyl)amino)phenoxysulfonyl-(2-(2-hydroxyethoxy)-4-chloro-6-methylpyridin-5-yl-methyl))methyl-2-nitrothiophene

There total 8 articles about 3-(4-(N,N-bis-(2-chloroethyl)amino)phenoxysulfonyl-(2-(2-hydroxyethoxy)-4-chloro-6-methylpyridin-5-yl-methyl))methyl-2-nitrothiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1196072-21-5
TH-1474

: 1196072-22-6
3-(4-(N,N-bis-(2-chloroethyl)amino)phenoxysulfonyl-(2-(2-hydroxyethoxy)-4-chloro-6-methylpyridin-5-yl-methyl))methyl-2-nitrothiophene

Guidance literature:: With trifluoroacetic acid; In water; at 20 ℃; for 1h;

Reference yield:

: 6373-46-2
p-benzyloxyaniline

: 1196072-22-6
3-(4-(N,N-bis-(2-chloroethyl)amino)phenoxysulfonyl-(2-(2-hydroxyethoxy)-4-chloro-6-methylpyridin-5-yl-methyl))methyl-2-nitrothiophene

Guidance literature:: Multi-step reaction with 7 steps

1: acetic acid / water / -78 - 20 °C

2: trichlorophosphate / 1 h / 100 °C

3: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethanol; water; ethyl acetate / 3 h

4: triethylamine / dichloromethane / 0 - 20 °C

5: potassium tert-butylate / tetrahydrofuran; dichloromethane / 1 h / -50 °C

6: di-isopropyl azodicarboxylate; triphenylphosphine / toluene / 0 - 20 °C

7: trifluoroacetic acid / water / 1 h / 20 °C

With hydrogenchloride; di-isopropyl azodicarboxylate; potassium tert-butylate; hydrogen; acetic acid; triethylamine; triphenylphosphine; trifluoroacetic acid; trichlorophosphate; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate; toluene; 6: Mitsunobu reaction;

Reference yield:

: 17794-35-3
benzyl-p-(bis-2-chloroethylamino)phenyl ester

: 1196072-22-6
3-(4-(N,N-bis-(2-chloroethyl)amino)phenoxysulfonyl-(2-(2-hydroxyethoxy)-4-chloro-6-methylpyridin-5-yl-methyl))methyl-2-nitrothiophene

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethanol; water; ethyl acetate / 3 h

2: triethylamine / dichloromethane / 0 - 20 °C

3: potassium tert-butylate / tetrahydrofuran; dichloromethane / 1 h / -50 °C

4: di-isopropyl azodicarboxylate; triphenylphosphine / toluene / 0 - 20 °C

5: trifluoroacetic acid / water / 1 h / 20 °C

With hydrogenchloride; di-isopropyl azodicarboxylate; potassium tert-butylate; hydrogen; triethylamine; triphenylphosphine; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate; toluene; 4: Mitsunobu reaction;