17794-35-3Relevant articles and documents
HYPOXIA ACTIVATED DRUGS OF NITROGEN MUSTARD ALKYLATORS
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, (2009/12/23)
Hypoxia activated drug compounds having a structure of formula(I) are useful in the treatment of cancer and other hyperproliferative diseases.
Melanocyte-directed enzyme prodrug therapy (MDEPT): Development of a targeted treatment for malignant melanoma
Jordan, Allan M.,Khan, Tariq H.,Osborn, Helen M. I.,Photiou, Andrew,Riley, Patrick A.
, p. 1775 - 1780 (2007/10/03)
A novel prodrug rationally designed to function as a tyrosinase substrate has been synthesised to allow targeted treatment of malignant melanoma. This agent has been evaluated for tyrosinase-mediated drug release, and has been shown to act in the desired
Glucuronide prodrugs of hydroxy compounds for antibody directed enzyme prodrug therapy (adept): A phenol nitrogen mustard carbamate
Schmidt,Florent,Monneret,Straub,Czech,Gerken,Bosslet
, p. 1071 - 1076 (2007/10/03)
A prodrug consisting of a β-D-glucuronic acid linked to a self-immolative spacer (a N-(ortho-hydroxyphenyl)-N-methylcarbamate) and a phenolic nitrogen mustard was synthesised. As this prodrug was easily cleaved by a β-glucuronidase enzyme and displayed lo