N-(2,6-difluorobenzyl)-5-(2-methyl-4-(trifluoromethyl)-1H-imidazol-1-yl)pyridin-2-amine

Base Information

Chemical Name:N-(2,6-difluorobenzyl)-5-(2-methyl-4-(trifluoromethyl)-1H-imidazol-1-yl)pyridin-2-amine
CAS No.:1415640-60-6
Molecular Formula:C₁₇H₁₃F₅N₄
Molecular Weight:368.309
Hs Code.:

Synonyms:N-(2,6-difluorobenzyl)-5-(2-methyl-4-(trifluoromethyl)-1H-imidazol-1-yl)pyridin-2-amine

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Chemical Property of N-(2,6-difluorobenzyl)-5-(2-methyl-4-(trifluoromethyl)-1H-imidazol-1-yl)pyridin-2-amine

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Technology Process of N-(2,6-difluorobenzyl)-5-(2-methyl-4-(trifluoromethyl)-1H-imidazol-1-yl)pyridin-2-amine

There total 5 articles about N-(2,6-difluorobenzyl)-5-(2-methyl-4-(trifluoromethyl)-1H-imidazol-1-yl)pyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.5%

: 1415640-59-3
(2,6-difluorophenyl)-N-{5-[2-methyl-4-(trifluoromethyl)imidazolyl](2-pyridyl)}carboxamide

: 1415640-60-6
N-(2,6-difluorobenzyl)-5-(2-methyl-4-(trifluoromethyl)-1H-imidazol-1-yl)pyridin-2-amine

Guidance literature:: (2,6-difluorophenyl)-N-{5-[2-methyl-4-(trifluoromethyl)imidazolyl](2-pyridyl)}carboxamide; With borane-THF; In tetrahydrofuran; at 50 ℃; for 5h;

With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃; for 2h;

With sodium hydrogencarbonate; In tetrahydrofuran; water; ethyl acetate;

Reference yield:

: 39856-50-3
5-bromo2-nitropyridine

: 1415640-60-6
N-(2,6-difluorobenzyl)-5-(2-methyl-4-(trifluoromethyl)-1H-imidazol-1-yl)pyridin-2-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / dimethyl sulfoxide / 0.5 h / 120 °C

1.2: 4 h / 120 °C

2.1: tin(II) chloride dihdyrate / ethyl acetate; N,N-dimethyl-formamide / 50 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

3.3: 2 h / 20 °C

4.1: borane-THF / tetrahydrofuran / 5 h / 50 °C

4.2: 2 h / 20 °C

With borane-THF; tin(II) chloride dihdyrate; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1415640-58-2
C₁₀H₉F₃N₄

: 1415640-60-6
N-(2,6-difluorobenzyl)-5-(2-methyl-4-(trifluoromethyl)-1H-imidazol-1-yl)pyridin-2-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

1.3: 2 h / 20 °C

2.1: borane-THF / tetrahydrofuran / 5 h / 50 °C

2.2: 2 h / 20 °C

With borane-THF; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;