(1R,2R)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)-4-methoxycyclopentanecarboxylic acid

Base Information

Chemical Name:(1R,2R)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)-4-methoxycyclopentanecarboxylic acid
CAS No.:1445592-12-0
Molecular Formula:C₁₆H₁₇BrN₂O₃
Molecular Weight:365.227
Hs Code.:

Synonyms:(1R,2R)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)-4-methoxycyclopentanecarboxylic acid

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Chemical Property of (1R,2R)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)-4-methoxycyclopentanecarboxylic acid

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Technology Process of (1R,2R)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)-4-methoxycyclopentanecarboxylic acid

There total 6 articles about (1R,2R)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)-4-methoxycyclopentanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1445592-11-9
(1R,2R)-tert-butyl 2-(5-(4-bromophenyl)-1H-imidazol-2-yl)-4-methoxycyclopentanecarboxylate

: 1445592-12-0
(1R,2R)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)-4-methoxycyclopentanecarboxylic acid

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃; for 4h;

Reference yield:

: 1445593-42-9
(1R,2R)-1-tert-butyl 2-methyl 4-oxocyclopentane-1,2-dicarboxylate

: 1445592-12-0
(1R,2R)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)-4-methoxycyclopentanecarboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium tetrahydroborate / methanol / 0 °C

2.1: silver trifluoromethanesulfonate; 2,6-dimethylpyridine / dichloromethane / 1 h / 0 - 20 °C

3.1: lithium hydroxide / water; acetonitrile; tetrahydrofuran / 7 h

3.2: pH Ca_. 4

4.1: acetonitrile / 5 h / 20 °C / Inert atmosphere

5.1: ammonium acetate / toluene / 6 h / 100 °C / Sealed tube

6.1: hydrogenchloride / water; tetrahydrofuran / 4 h / 20 °C

With 2,6-dimethylpyridine; hydrogenchloride; sodium tetrahydroborate; ammonium acetate; silver trifluoromethanesulfonate; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; toluene; acetonitrile;

Reference yield:

: 1445592-09-5
(1R,2R)-1-tert-butyl 2-methyl 4-methoxycyclopentane-1,2-dicarboxylate

: 1445592-12-0
(1R,2R)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)-4-methoxycyclopentanecarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hydroxide / water; acetonitrile; tetrahydrofuran / 7 h

1.2: pH Ca_. 4

2.1: acetonitrile / 5 h / 20 °C / Inert atmosphere

3.1: ammonium acetate / toluene / 6 h / 100 °C / Sealed tube

4.1: hydrogenchloride / water; tetrahydrofuran / 4 h / 20 °C

With hydrogenchloride; ammonium acetate; lithium hydroxide; In tetrahydrofuran; water; toluene; acetonitrile;