(1R,2R)-tert-butyl 2-(5-(4-bromophenyl)-1H-imidazol-2-yl)-4-methoxycyclopentanecarboxylate

Base Information

Chemical Name:(1R,2R)-tert-butyl 2-(5-(4-bromophenyl)-1H-imidazol-2-yl)-4-methoxycyclopentanecarboxylate
CAS No.:1445592-11-9
Molecular Formula:C₂₀H₂₅BrN₂O₃
Molecular Weight:421.334
Hs Code.:

Synonyms:(1R,2R)-tert-butyl 2-(5-(4-bromophenyl)-1H-imidazol-2-yl)-4-methoxycyclopentanecarboxylate

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Chemical Property of (1R,2R)-tert-butyl 2-(5-(4-bromophenyl)-1H-imidazol-2-yl)-4-methoxycyclopentanecarboxylate

Chemical Property:

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Technology Process of (1R,2R)-tert-butyl 2-(5-(4-bromophenyl)-1H-imidazol-2-yl)-4-methoxycyclopentanecarboxylate

There total 5 articles about (1R,2R)-tert-butyl 2-(5-(4-bromophenyl)-1H-imidazol-2-yl)-4-methoxycyclopentanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₀H₂₅BrO₆

: 1445592-11-9
(1R,2R)-tert-butyl 2-(5-(4-bromophenyl)-1H-imidazol-2-yl)-4-methoxycyclopentanecarboxylate

Guidance literature:: With ammonium acetate; In toluene; at 100 ℃; for 6h; Sealed tube;

Reference yield:

: 1445593-42-9
(1R,2R)-1-tert-butyl 2-methyl 4-oxocyclopentane-1,2-dicarboxylate

: 1445592-11-9
(1R,2R)-tert-butyl 2-(5-(4-bromophenyl)-1H-imidazol-2-yl)-4-methoxycyclopentanecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate / methanol / 0 °C

2.1: silver trifluoromethanesulfonate; 2,6-dimethylpyridine / dichloromethane / 1 h / 0 - 20 °C

3.1: lithium hydroxide / water; acetonitrile; tetrahydrofuran / 7 h

3.2: pH Ca_. 4

4.1: acetonitrile / 5 h / 20 °C / Inert atmosphere

5.1: ammonium acetate / toluene / 6 h / 100 °C / Sealed tube

With 2,6-dimethylpyridine; sodium tetrahydroborate; ammonium acetate; silver trifluoromethanesulfonate; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; toluene; acetonitrile;

Reference yield:

: 1445592-09-5
(1R,2R)-1-tert-butyl 2-methyl 4-methoxycyclopentane-1,2-dicarboxylate

: 1445592-11-9
(1R,2R)-tert-butyl 2-(5-(4-bromophenyl)-1H-imidazol-2-yl)-4-methoxycyclopentanecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hydroxide / water; acetonitrile; tetrahydrofuran / 7 h

1.2: pH Ca_. 4

2.1: acetonitrile / 5 h / 20 °C / Inert atmosphere

3.1: ammonium acetate / toluene / 6 h / 100 °C / Sealed tube

With ammonium acetate; lithium hydroxide; In tetrahydrofuran; water; toluene; acetonitrile;