5-Hydroxy-2-[1-methyl-1-[[benzylcarbamoyl]amino]ethyl]-6-methoxypyrimidine-4-carboxylic Acid Methyl Ester

Base Information

Chemical Name:5-Hydroxy-2-[1-methyl-1-[[benzylcarbamoyl]amino]ethyl]-6-methoxypyrimidine-4-carboxylic Acid Methyl Ester
CAS No.:1159977-42-0
Molecular Formula:C₁₈H₂₁N₃O₆
Molecular Weight:375.381
Hs Code.:
Mol file:1159977-42-0.mol

Synonyms:C₁₈H₂₁N₃O₆

Suppliers and Price of 5-Hydroxy-2-[1-methyl-1-[[benzylcarbamoyl]amino]ethyl]-6-methoxypyrimidine-4-carboxylic Acid Methyl Ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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TRC
5-Hydroxy-2-[1-methyl-1-[[benzylcarbamoyl]amino]ethyl]-6-methoxypyrimidine-4-carboxylicAcidMethylEster
25mg
$ 165.00

Total 0 raw suppliers

Chemical Property of 5-Hydroxy-2-[1-methyl-1-[[benzylcarbamoyl]amino]ethyl]-6-methoxypyrimidine-4-carboxylic Acid Methyl Ester

Chemical Property:

Melting Point:108-112°C
Storage Temp.:Refrigerator
Solubility.:DMSO (Slightly), Methanol (Slightly)

Purity/Quality:: 5-Hydroxy-2-[1-methyl-1-[[benzylcarbamoyl]amino]ethyl]-6-methoxypyrimidine-4-carboxylicAcidMethylEster ^*data from reagent suppliers

Safty Information:

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Hazard Codes:

MSDS Files:

Useful:

Uses An impurity of the commercial synthesis of Raltegravir

Technology Process of 5-Hydroxy-2-[1-methyl-1-[[benzylcarbamoyl]amino]ethyl]-6-methoxypyrimidine-4-carboxylic Acid Methyl Ester

There total 8 articles about 5-Hydroxy-2-[1-methyl-1-[[benzylcarbamoyl]amino]ethyl]-6-methoxypyrimidine-4-carboxylic Acid Methyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: methyl 2-(2(((benzyloxy)carbonyl)amino)propan-2-yl)-5,6-dihydroxy-1,6-dihydropyrimidine-4-carboxylate

: 74-88-4
methyl iodide

: 888504-27-6
2-(1-benzyloxycarbonylamino-1-methyl-ethyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydro-pyrimidine-4-carboxylic acid methyl ester

: 1159977-42-0
C₁₈H₂₁N₃O₆

Guidance literature:: With magnesium methanolate; In dimethyl sulfoxide; at 20 - 60 ℃; for 7h; Large scale reaction;
DOI:10.1021/op100257r

Reference yield:

: methyl 2-(2(((benzyloxy)carbonyl)amino)propan-2-yl)-5,6-dihydroxy-1,6-dihydropyrimidine-4-carboxylate

: 77-78-1
dimethyl sulfate

: 888504-27-6
2-(1-benzyloxycarbonylamino-1-methyl-ethyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydro-pyrimidine-4-carboxylic acid methyl ester

: 1159977-42-0
C₁₈H₂₁N₃O₆

Guidance literature:: With lithium tert-butoxide; In dimethyl sulfoxide; at 50 ℃;
DOI:10.1021/op100257r

Reference yield:

: 100134-82-5
(cyano-dimethyl-methyl)carbamic acid benzyl ester

: 888504-27-6
2-(1-benzyloxycarbonylamino-1-methyl-ethyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydro-pyrimidine-4-carboxylic acid methyl ester

: 1159977-42-0
C₁₈H₂₁N₃O₆

Guidance literature:: Multi-step reaction with 4 steps

1: hydroxylamine / water; isopropyl alcohol / 5.42 h / 58 - 60 °C / Large scale reaction

2: dimethyl sulfoxide / 20 °C

3: 5,5-dimethyl-1,3-cyclohexadiene / 135 °C

4: lithium tert-butoxide / N,N-dimethyl-formamide / 80 °C

With hydroxylamine; lithium tert-butoxide; In 5,5-dimethyl-1,3-cyclohexadiene; water; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol; 2: Michael condensation;
DOI:10.1021/op100257r