benzyl 1-(3-{(2R)-1-[4-(2-methoxyethoxy)benzyl]-5-oxopyrrolidin-2-yl}propyl)-1H-imidazole-4-carboxylate

Base Information

• Chemical Name: benzyl 1-(3-{(2R)-1-[4-(2-methoxyethoxy)benzyl]-5-oxopyrrolidin-2-yl}propyl)-1H-imidazole-4-carboxylate
• CAS No.: 1422064-15-0
• Molecular Formula: C₂₈H₃₃N₃O₅
• Molecular Weight: 491.587

Synonyms:benzyl 1-(3-{(2R)-1-[4-(2-methoxyethoxy)benzyl]-5-oxopyrrolidin-2-yl}propyl)-1H-imidazole-4-carboxylate

Chemical Property of benzyl 1-(3-{(2R)-1-[4-(2-methoxyethoxy)benzyl]-5-oxopyrrolidin-2-yl}propyl)-1H-imidazole-4-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl 1-(3-{(2R)-1-[4-(2-methoxyethoxy)benzyl]-5-oxopyrrolidin-2-yl}propyl)-1H-imidazole-4-carboxylate

There total 9 articles about benzyl 1-(3-{(2R)-1-[4-(2-methoxyethoxy)benzyl]-5-oxopyrrolidin-2-yl}propyl)-1H-imidazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

1H-imidazole-4(5)-carboxylic acid phenylmethyl ester (1208114-68-4) + 3-{(2R)-1-[4-(2-methoxyethoxy)benzyl]-5-oxopyrrolidin-2-yl}propyl 4-methylbenzenesulfonate (1422064-12-7) → benzyl 1-(3-{(2R)-1-[4-(2-methoxyethoxy)benzyl]-5-oxopyrrolidin-2-yl}propyl)-1H-imidazole-5-carboxylate (1422064-14-9) + benzyl 1-(3-{(2R)-1-[4-(2-methoxyethoxy)benzyl]-5-oxopyrrolidin-2-yl}propyl)-1H-imidazole-4-carboxylate (1422064-15-0)

Guidance literature:

1H-imidazole-4⁽⁵⁾-carboxylic acid phenylmethyl ester; With caesium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 0.5h; Inert atmosphere;

3-{(2R)-1-[4-(2-methoxyethoxy)benzyl]-5-oxopyrrolidin-2-yl}propyl 4-methylbenzenesulfonate; In N,N-dimethyl-formamide; at 50 ℃; Inert atmosphere;

DOI:10.3390/molecules18010050

Reference yield:

[4-(2-methoxyethoxy)phenyl]methanol (79407-30-0) → benzyl 1-(3-{(2R)-1-[4-(2-methoxyethoxy)benzyl]-5-oxopyrrolidin-2-yl}propyl)-1H-imidazole-4-carboxylate (1422064-15-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: phosphorus tribromide / diethyl ether / 20 °C / Inert atmosphere; Cooling with ice

2.1: sodium hydride / tetrahydrofuran; paraffin oil / 24.25 h / 0 - 20 °C / Inert atmosphere

3.1: lithium borohydride / tetrahydrofuran / 10 h / 20 °C / Inert atmosphere

4.1: triethylamine / dichloromethane / 0 - 20 °C

5.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 50 °C / Inert atmosphere

5.2: 50 °C / Inert atmosphere

With lithium borohydride; phosphorus tribromide; sodium hydride; caesium carbonate; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; paraffin oil;

DOI:10.3390/molecules18010050

Reference yield:

methyl 3-{(2S)-1-[4-(2-methoxyethoxy)benzyl]-5-oxopyrrolidin-2-yl} propanoate (1422064-10-5) → benzyl 1-(3-{(2R)-1-[4-(2-methoxyethoxy)benzyl]-5-oxopyrrolidin-2-yl}propyl)-1H-imidazole-4-carboxylate (1422064-15-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium borohydride / tetrahydrofuran / 10 h / 20 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 0 - 20 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 50 °C / Inert atmosphere

3.2: 50 °C / Inert atmosphere

With lithium borohydride; caesium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.3390/molecules18010050

upstream raw materials:

[4-(2-methoxyethoxy)phenyl]methanol

methyl 3-{(2S)-1-[4-(2-methoxyethoxy)benzyl]-5-oxopyrrolidin-2-yl} propanoate

1-(bromomethyl)-4-(2-methoxyethoxy)benzene

methyl 3-[(2S)-5-oxopyrrolidin-2-yl]propanoate

Downstream raw materials:

1-(3-{(2R)-1-[4-(2-methoxyethoxy)benzyl]-5-oxopyrrolidin-2-yl}propyl)-1H-imidazole-4-carboxylic acid

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1422064-15-0 benzyl 1-(3-{(2R)-1-[4-(2-methoxyethoxy)benzyl]-5-oxopyrrolidin-2-yl}propyl)-1H-imidazole-4-carboxylate

Send

Send

Metric Ton KG G Pound L ML

Send

Send