1-(3-{(2R)-1-[4-(2-methoxyethoxy)benzyl]-5-oxopyrrolidin-2-yl}propyl)-1H-imidazole-4-carboxylic acid

Base Information

Chemical Name:1-(3-{(2R)-1-[4-(2-methoxyethoxy)benzyl]-5-oxopyrrolidin-2-yl}propyl)-1H-imidazole-4-carboxylic acid
CAS No.:1422064-17-2
Molecular Formula:C₂₁H₂₇N₃O₅
Molecular Weight:401.462
Hs Code.:

Synonyms:1-(3-{(2R)-1-[4-(2-methoxyethoxy)benzyl]-5-oxopyrrolidin-2-yl}propyl)-1H-imidazole-4-carboxylic acid

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Chemical Property of 1-(3-{(2R)-1-[4-(2-methoxyethoxy)benzyl]-5-oxopyrrolidin-2-yl}propyl)-1H-imidazole-4-carboxylic acid

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Technology Process of 1-(3-{(2R)-1-[4-(2-methoxyethoxy)benzyl]-5-oxopyrrolidin-2-yl}propyl)-1H-imidazole-4-carboxylic acid

There total 10 articles about 1-(3-{(2R)-1-[4-(2-methoxyethoxy)benzyl]-5-oxopyrrolidin-2-yl}propyl)-1H-imidazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1422064-15-0
benzyl 1-(3-{(2R)-1-[4-(2-methoxyethoxy)benzyl]-5-oxopyrrolidin-2-yl}propyl)-1H-imidazole-4-carboxylate

: 1422064-17-2
1-(3-{(2R)-1-[4-(2-methoxyethoxy)benzyl]-5-oxopyrrolidin-2-yl}propyl)-1H-imidazole-4-carboxylic acid

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; under 760.051 Torr;
DOI:10.3390/molecules18010050

Reference yield:

: 79407-30-0
[4-(2-methoxyethoxy)phenyl]methanol

: 1422064-17-2
1-(3-{(2R)-1-[4-(2-methoxyethoxy)benzyl]-5-oxopyrrolidin-2-yl}propyl)-1H-imidazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: phosphorus tribromide / diethyl ether / 20 °C / Inert atmosphere; Cooling with ice

2.1: sodium hydride / tetrahydrofuran; paraffin oil / 24.25 h / 0 - 20 °C / Inert atmosphere

3.1: lithium borohydride / tetrahydrofuran / 10 h / 20 °C / Inert atmosphere

4.1: triethylamine / dichloromethane / 0 - 20 °C

5.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 50 °C / Inert atmosphere

5.2: 50 °C / Inert atmosphere

6.1: palladium 10% on activated carbon; hydrogen / methanol / 760.05 Torr

With lithium borohydride; palladium 10% on activated carbon; hydrogen; phosphorus tribromide; sodium hydride; caesium carbonate; triethylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; paraffin oil;
DOI:10.3390/molecules18010050

Reference yield:

: 1422064-10-5
methyl 3-{(2S)-1-[4-(2-methoxyethoxy)benzyl]-5-oxopyrrolidin-2-yl} propanoate

: 1422064-17-2
1-(3-{(2R)-1-[4-(2-methoxyethoxy)benzyl]-5-oxopyrrolidin-2-yl}propyl)-1H-imidazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium borohydride / tetrahydrofuran / 10 h / 20 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 0 - 20 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 50 °C / Inert atmosphere

3.2: 50 °C / Inert atmosphere

4.1: palladium 10% on activated carbon; hydrogen / methanol / 760.05 Torr

With lithium borohydride; palladium 10% on activated carbon; hydrogen; caesium carbonate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.3390/molecules18010050