C₂₀H₂₃ClO₄

Base Information

• Chemical Name: C₂₀H₂₃ClO₄
• CAS No.: 1448680-63-4
• Molecular Formula: C₂₀H₂₃ClO₄
• Molecular Weight: 362.853
• Mol file: 1448680-63-4.mol

Synonyms:C₂₀H₂₃ClO₄

Chemical Property of C₂₀H₂₃ClO₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₀H₂₃ClO₄

There total 9 articles about C₂₀H₂₃ClO₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

C22H27ClO4 (1448680-57-6) → C20H23ClO4 (1448680-63-4)

Guidance literature:

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; at 0 - 20 ℃; for 8h; Inert atmosphere;

DOI:10.1021/jm400515c

Reference yield:

D-glucal triacetate (2873-29-2) → C20H23ClO4 (1448680-63-4)

Guidance literature:

Multi-step reaction with 8 steps

1.1: boron trifluoride diethyl etherate / dichloromethane / 2 h / -10 °C

2.1: sodium methylate / methanol / 0.5 h / 20 °C

2.2: amberlyte (IR 120 H⁺) resin

3.1: p-toluenesulfonyl chloride; pyridine / 8 h / 0 - 20 °C

4.1: dimethyl sulfoxide / 4 h / 70 °C

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 4 h / 0 - 20 °C

6.1: sodium hydroxide / ethanol / Reflux

6.2: 20 °C

7.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 14 h / 0 - 25 °C

8.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 8 h / 0 - 20 °C / Inert atmosphere

With pyridine; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; dmap; boron trifluoride diethyl etherate; sodium methylate; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; p-toluenesulfonyl chloride; sodium hydroxide; In methanol; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;

DOI:10.1021/jm400515c

Reference yield:

(2R,3S,6R)-6-allyl-2-hydroxymethyl-3,6-dihydro-2H-pyran-3-ol (95791-07-4) → C20H23ClO4 (1448680-63-4)

Guidance literature:

Multi-step reaction with 6 steps

1.1: p-toluenesulfonyl chloride; pyridine / 8 h / 0 - 20 °C

2.1: dimethyl sulfoxide / 4 h / 70 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 4 h / 0 - 20 °C

4.1: sodium hydroxide / ethanol / Reflux

4.2: 20 °C

5.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 14 h / 0 - 25 °C

6.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 8 h / 0 - 20 °C / Inert atmosphere

With pyridine; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; dmap; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; p-toluenesulfonyl chloride; sodium hydroxide; In ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;

DOI:10.1021/jm400515c

upstream raw materials:

D-glucal triacetate

(2R,3S,6R)-2-acetoxymethyl-6-allyl-3,6-dihydro-2H-pyran-3-yl acetate

(2R,3S,6R)-6-allyl-2-hydroxymethyl-3,6-dihydro-2H-pyran-3-ol

toluene-4-sulfonic acid 6-Allyl-3-hydroxy-3,6-dihydro-2H-pyran-2-ylmethyl ester