2-chloro-4-tert-butyldiphenylsilyloxybutanoic acid

Base Information

Chemical Name:2-chloro-4-tert-butyldiphenylsilyloxybutanoic acid
CAS No.:768401-41-8
Molecular Formula:C₂₀H₂₅ClO₃Si
Molecular Weight:376.955
Hs Code.:

Synonyms:2-chloro-4-tert-butyldiphenylsilyloxybutanoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-chloro-4-tert-butyldiphenylsilyloxybutanoic acid

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Technology Process of 2-chloro-4-tert-butyldiphenylsilyloxybutanoic acid

There total 2 articles about 2-chloro-4-tert-butyldiphenylsilyloxybutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 768401-38-3
methyl 2-chloro-4-tert-butyldiphenylsilyloxybutanoate

: 768401-41-8
2-chloro-4-tert-butyldiphenylsilyloxybutanoic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; water; at 0 ℃;
DOI:10.1016/j.tet.2004.06.085

Reference yield:

: 179690-96-1
methyl 4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]butanoate

: 768401-41-8
2-chloro-4-tert-butyldiphenylsilyloxybutanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 68 percent / n-BuLi; diisopropylamine; CCl₄ / tetrahydrofuran; hexane / 0.08 h / -78 °C

2: 94 percent / LiOH*H₂O / tetrahydrofuran; H₂O / 0 °C

With tetrachloromethane; lithium hydroxide; n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; water;
DOI:10.1016/j.tet.2004.06.085

Reference yield: 95.0%

: 768401-41-8
2-chloro-4-tert-butyldiphenylsilyloxybutanoic acid

: 768401-44-1
2-chloro-4-tert-butyldiphenylsilyloxybutanoyl chloride

Guidance literature:: With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 - 15 ℃; for 0.5h;
DOI:10.1016/j.tet.2004.06.085