179690-96-1Relevant articles and documents
Model studies related to CP-225,917: Stereocontrolled generation of the quaternary center
Clive, Derrick L. J.,Zhang, Junhu
, p. 12059 - 12068 (1999)
The enolate derived from ester 15 reacts with diketone 10 stereoselectively (10:1), and the major isomer can be converted into lactone 21. This rearranges in boiling 1,2-dichlorobenzene to afford the tricyclic lactone 22, a model compound which shares wit
Diastereoselective synthesis of the C17-C30 fragment of amphidinol 3
Rival, Nicolas,Hazelard, Damien,Hanquet, Gilles,Kreuzer, Thomas,Bensoussan, Charlelie,Reymond, Sébastien,Cossy, Janine,Colobert, Fran?oise
supporting information, p. 9418 - 9428 (2013/01/15)
The diastereoselective synthesis of the C17-C30 fragment of amphidinol 3 (AM3) 1 was achieved from the enantio-enriched aldehyde 20, Weinreb amide 14 and 2-bromo-3-(trimethylsilyl)propene, which was used as a bifunctional conjunctive reagent. The absolute configuration of the stereogenic centers, in both aldehyde 20 and Weinreb amide 14, were efficiently controlled by using (+)-(R)-methyl-p-tolylsulfoxide as the unique source of chirality.