(1S,2R)-{1-benzyl-2-hydroxy-3-[isobutyl(4-methoxybenzenesulfonyl)amino]propyl}carbamic acid (1S)-3,5-dioxacyclooctan-1-yl ester

Base Information

Chemical Name:(1S,2R)-{1-benzyl-2-hydroxy-3-[isobutyl(4-methoxybenzenesulfonyl)amino]propyl}carbamic acid (1S)-3,5-dioxacyclooctan-1-yl ester
CAS No.:1067244-17-0
Molecular Formula:C₂₈H₄₀N₂O₈S
Molecular Weight:564.7
Hs Code.:

Synonyms:(1S,2R)-{1-benzyl-2-hydroxy-3-[isobutyl(4-methoxybenzenesulfonyl)amino]propyl}carbamic acid (1S)-3,5-dioxacyclooctan-1-yl ester

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Chemical Property of (1S,2R)-{1-benzyl-2-hydroxy-3-[isobutyl(4-methoxybenzenesulfonyl)amino]propyl}carbamic acid (1S)-3,5-dioxacyclooctan-1-yl ester

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Technology Process of (1S,2R)-{1-benzyl-2-hydroxy-3-[isobutyl(4-methoxybenzenesulfonyl)amino]propyl}carbamic acid (1S)-3,5-dioxacyclooctan-1-yl ester

There total 7 articles about (1S,2R)-{1-benzyl-2-hydroxy-3-[isobutyl(4-methoxybenzenesulfonyl)amino]propyl}carbamic acid (1S)-3,5-dioxacyclooctan-1-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1067244-61-4
(S)-1-(4-nitrophenoxycarbonyloxy)-3,5-dioxacyclooctane

: 159005-71-7
N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-N-isobutyl-4-methoxybenzenesulfonamide

: 1067244-17-0
(1S,2R)-{1-benzyl-2-hydroxy-3-[isobutyl(4-methoxybenzenesulfonyl)amino]propyl}carbamic acid (1S)-3,5-dioxacyclooctan-1-yl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; at 23 ℃; for 48h; Inert atmosphere;
DOI:10.1021/jm8004543

Reference yield:

: 1067244-40-9
(S)-2-(tert-butyldiphenylsilyloxy)pentadioic acid dimethyl ester

: 1067244-17-0
(1S,2R)-{1-benzyl-2-hydroxy-3-[isobutyl(4-methoxybenzenesulfonyl)amino]propyl}carbamic acid (1S)-3,5-dioxacyclooctan-1-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: lithium borohydride; methanol / diethyl ether / 24 h / 0 - 23 °C

2: boron trifluoride diethyl etherate / ethyl acetate / 4 h / 23 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 23 °C

4: 4-methyl-morpholine / tetrahydrofuran / 1 h / 23 °C

5: N-ethyl-N,N-diisopropylamine / dichloromethane; tetrahydrofuran / 48 h

With 4-methyl-morpholine; methanol; lithium borohydride; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; diethyl ether; dichloromethane; ethyl acetate;

Reference yield:

: 1067244-41-0
(2S)-2-(tert-butyldiphenylsilyloxy)pentane-1,5-diol

: 1067244-17-0
(1S,2R)-{1-benzyl-2-hydroxy-3-[isobutyl(4-methoxybenzenesulfonyl)amino]propyl}carbamic acid (1S)-3,5-dioxacyclooctan-1-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: boron trifluoride diethyl etherate / ethyl acetate / 4 h / 23 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 23 °C

3: 4-methyl-morpholine / tetrahydrofuran / 1 h / 23 °C

4: N-ethyl-N,N-diisopropylamine / dichloromethane; tetrahydrofuran / 48 h

With 4-methyl-morpholine; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; ethyl acetate;