Carbamic acid, [(1S,2R)-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino ]-1-(phenylmethyl)propyl]-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: Carbamic acid, [(1S,2R)-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino ]-1-(phenylmethyl)propyl]-, 1,1-dimethylethyl ester
• CAS No.: 159006-03-8
• Molecular Formula: C26H38N2O6S
• Molecular Weight: 506.664
• Mol file: 159006-03-8.mol

Synonyms:{(1S,2R)-1-Benzyl-2-hydroxy-3-[isobutyl-(4-methoxy-benzenesulfonyl)-amino]-propyl}-carbamic acid tert-butyl ester;((1S,2R)-1-benzyl-2-hydroxy-3-{[4-methoxybenzenesulfonyl]isobutylamino}propyl)carbamic acid tert-butyl ester;N-[(1S,2R)-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester;N-[(1S,2R)-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-(phenylmethyl)propyl]-carbamic acid tert-butyl ester;N-[(1S,2R)-1-benzyl-2-hydroxy-3-[isobutyl[(4-methoxyphenyl)sulfonyl]amino]propyl]carbamic acid tert-butyl ester;

Chemical Property of Carbamic acid, [(1S,2R)-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino ]-1-(phenylmethyl)propyl]-, 1,1-dimethylethyl ester

Chemical Property:

• PSA: 113.55000
• LogP: 5.31050

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Carbamic acid, [(1S,2R)-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino ]-1-(phenylmethyl)propyl]-, 1,1-dimethylethyl ester

There total 9 articles about Carbamic acid, [(1S,2R)-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino ]-1-(phenylmethyl)propyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.7%

4-methoxy-phenyl-sulphonyl chloride (98-68-0) + (2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol (160232-08-6) → tert-butyl (1S,2R)-1-benzyl-2-hydroxy-3-{isobutyl[(4-methoxyphenyl)sulfonyl]amino}propylcarbamate (159006-03-8)

Guidance literature:

With dmap; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 - 25 ℃; for 4h;

DOI:10.1016/j.ejmech.2021.113450

Reference yield: 92.0%

isobutylamine (78-81-9) + (2R,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1,2-epoxy-4-phenylbutane (98760-08-8) + 4-methoxy-phenyl-sulphonyl chloride (98-68-0) → tert-butyl (1S,2R)-1-benzyl-2-hydroxy-3-{isobutyl[(4-methoxyphenyl)sulfonyl]amino}propylcarbamate (159006-03-8)

Guidance literature:

isobutylamine; (2R,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1,2-epoxy-4-phenylbutane; In isopropyl alcohol; at 80 ℃; for 2h;

4-methoxy-phenyl-sulphonyl chloride; With triethylamine; In dichloromethane; at 25 ℃; for 1h;

Reference yield: 87.0%

isobutylamine (78-81-9) + (1-oxiranyl-2-phenylethyl)carbamic acid tert-butyl ester (98760-08-8,98818-34-9,98818-35-0,103127-56-6,98737-29-2) + 4-methoxy-phenyl-sulphonyl chloride (98-68-0) → tert-butyl (1S,2R)-1-benzyl-2-hydroxy-3-{isobutyl[(4-methoxyphenyl)sulfonyl]amino}propylcarbamate (159006-03-8)

Guidance literature:

isobutylamine; (1-oxiranyl-2-phenylethyl)carbamic acid tert-butyl ester; In isopropyl alcohol; at 60 ℃; for 6h;

4-methoxy-phenyl-sulphonyl chloride; With triethylamine; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1021/acs.orglett.1c01964

upstream raw materials:

4-methoxy-phenyl-sulphonyl chloride

(2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol

(1-oxiranyl-2-phenylethyl)carbamic acid tert-butyl ester

(2S,3S)-3-Amino-1-benzyloxy-4-phenyl-butan-2-ol

Downstream raw materials:

N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-N-isobutyl-4-methoxybenzenesulfonamide

3-(3-acetyl-phenyl)-2-oxo-oxazolidine-5-carboxylic acid {1-benzyl-2-hydroxy-3-[isobutyl-(4-methoxy-benzenesulfonyl)-amino]-propyl}-amide