2-{[5-[4-(4-hydroxymethyl-[1,2,3]triazol-1-yl)-phenyl]-4-(4-methoxy-phenyl)-thiazol-2-yl]-hydrazono}-3-(2-nitro-phenyl)-propionic acid

Base Information

Chemical Name:2-{[5-[4-(4-hydroxymethyl-[1,2,3]triazol-1-yl)-phenyl]-4-(4-methoxy-phenyl)-thiazol-2-yl]-hydrazono}-3-(2-nitro-phenyl)-propionic acid
CAS No.:1354964-54-7
Molecular Formula:C₂₈H₂₃N₇O₆S
Molecular Weight:585.6
Hs Code.:

Synonyms:2-{[5-[4-(4-hydroxymethyl-[1,2,3]triazol-1-yl)-phenyl]-4-(4-methoxy-phenyl)-thiazol-2-yl]-hydrazono}-3-(2-nitro-phenyl)-propionic acid

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Chemical Property of 2-{[5-[4-(4-hydroxymethyl-[1,2,3]triazol-1-yl)-phenyl]-4-(4-methoxy-phenyl)-thiazol-2-yl]-hydrazono}-3-(2-nitro-phenyl)-propionic acid

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Technology Process of 2-{[5-[4-(4-hydroxymethyl-[1,2,3]triazol-1-yl)-phenyl]-4-(4-methoxy-phenyl)-thiazol-2-yl]-hydrazono}-3-(2-nitro-phenyl)-propionic acid

There total 6 articles about 2-{[5-[4-(4-hydroxymethyl-[1,2,3]triazol-1-yl)-phenyl]-4-(4-methoxy-phenyl)-thiazol-2-yl]-hydrazono}-3-(2-nitro-phenyl)-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1354964-91-2
2-{[5-(4-azido-phenyl)-4-(4-methoxy-phenyl)-thiazol-2-yl]-hydrazono}-3-(2-nitro-phenyl)-propionic acid

: 107-19-7
propargyl alcohol

: 1354964-54-7
2-{[5-[4-(4-hydroxymethyl-[1,2,3]triazol-1-yl)-phenyl]-4-(4-methoxy-phenyl)-thiazol-2-yl]-hydrazono}-3-(2-nitro-phenyl)-propionic acid

Guidance literature:: With N-ethyl-N,N-diisopropylamine; copper(l) iodide; In acetonitrile; tert-butyl alcohol; at 20 ℃;

Reference yield:

: 100-66-3
methoxybenzene

: 1354964-54-7
2-{[5-[4-(4-hydroxymethyl-[1,2,3]triazol-1-yl)-phenyl]-4-(4-methoxy-phenyl)-thiazol-2-yl]-hydrazono}-3-(2-nitro-phenyl)-propionic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: polyphoshoric acid / dichloromethane / 0.17 h / 80 °C

1.2: 2 h / 80 °C

1.3: Cooling with ice

2.1: trifluoroacetic acid; sodium nitrite / 1 h / 0 °C

2.2: 1.33 h / 0 - 20 °C / Darkness

3.1: bromine / dichloromethane / 0.08 h

4.1: 1,4-dioxane / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / copper(l) iodide / acetonitrile; tert-butyl alcohol / 20 °C

With bromine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium nitrite; copper(l) iodide; In 1,4-dioxane; dichloromethane; acetonitrile; tert-butyl alcohol;

Reference yield:

: 1197-55-3
4-aminophenylacetic acid

: 1354964-54-7
2-{[5-[4-(4-hydroxymethyl-[1,2,3]triazol-1-yl)-phenyl]-4-(4-methoxy-phenyl)-thiazol-2-yl]-hydrazono}-3-(2-nitro-phenyl)-propionic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: polyphoshoric acid / dichloromethane / 0.17 h / 80 °C

1.2: 2 h / 80 °C

1.3: Cooling with ice

2.1: trifluoroacetic acid; sodium nitrite / 1 h / 0 °C

2.2: 1.33 h / 0 - 20 °C / Darkness

3.1: bromine / dichloromethane / 0.08 h

4.1: 1,4-dioxane / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / copper(l) iodide / acetonitrile; tert-butyl alcohol / 20 °C

With bromine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium nitrite; copper(l) iodide; In 1,4-dioxane; dichloromethane; acetonitrile; tert-butyl alcohol;