1,2-⁽¹³⁾C₂-methyl 2-(benzyl(tert-butoxycarbonyl)amino)acetate

Base Information

• Chemical Name: 1,2-⁽¹³⁾C₂-methyl 2-(benzyl(tert-butoxycarbonyl)amino)acetate
• CAS No.: 1384626-47-4
• Molecular Formula: C₁₅H₂₁NO₄
• Molecular Weight: 281.314
• Mol file: 1384626-47-4.mol

Synonyms:1,2-⁽¹³⁾C₂-methyl 2-(benzyl(tert-butoxycarbonyl)amino)acetate

Chemical Property of 1,2-⁽¹³⁾C₂-methyl 2-(benzyl(tert-butoxycarbonyl)amino)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,2-⁽¹³⁾C₂-methyl 2-(benzyl(tert-butoxycarbonyl)amino)acetate

There total 2 articles about 1,2-⁽¹³⁾C₂-methyl 2-(benzyl(tert-butoxycarbonyl)amino)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1,2-(13)C2-2-(benzyl(tert-butoxycarbonyl)amino)acetic acid (1384626-45-2) + methyl iodide (74-88-4) → 1,2-(13)C2-methyl 2-(benzyl(tert-butoxycarbonyl)amino)acetate (1384626-47-4)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.tetlet.2012.05.084

Reference yield:

1,2-(13)C2-2-(benzylamino)acetic acid (1384626-43-0) → 1,2-(13)C2-methyl 2-(benzyl(tert-butoxycarbonyl)amino)acetate (1384626-47-4)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / 1,4-dioxane; water / 2 h / 20 °C

2: caesium carbonate / N,N-dimethyl-formamide / 20 °C

With caesium carbonate; triethylamine; In 1,4-dioxane; water; N,N-dimethyl-formamide;

DOI:10.1016/j.tetlet.2012.05.084

Reference yield:

1,2-(13)C2-methyl 2-(benzyl(tert-butoxycarbonyl)amino)acetate (1384626-47-4) → (13)C4-methyl 2-(N-benzyl-2-(tert-butoxycarbonylamino)acetamido)acetate (1384626-56-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

2.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / 20 °C

2.2: 2 h / 20 °C

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;

DOI:10.1016/j.tetlet.2012.05.084

upstream raw materials:

1,2-⁽¹³⁾C₂-2-(benzylamino)acetic acid

1,2-⁽¹³⁾C₂-2-(benzyl(tert-butoxycarbonyl)amino)acetic acid

methyl iodide

Downstream raw materials:

⁽¹³⁾C₄-methyl 2-(N-benzyl-2-(tert-butoxycarbonylamino)acetamido)acetate

⁽¹³⁾C₄-1-benzylpiperazine-2,5-dione