Technology Process of 6α-fluoro-17α,21-dihydroxy-16β-methylpregna-4,9(11)-diene-3,20-dione 21-acetate
There total 1 articles about 6α-fluoro-17α,21-dihydroxy-16β-methylpregna-4,9(11)-diene-3,20-dione 21-acetate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
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6α-Fluor-16α-methylhydrocortison-(21)-acetat, Methylsulfochlorid, DMF, Py.;
DOI:10.1021/ja01494a054
- Guidance literature:
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Multi-step reaction with 4 steps
1: p-toluenesulfonic acid monohydrate; trifluoroacetic anhydride / methanol; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; dichloromethane; acetic acid
2: perchloric acid; potassium acetate; sodium sulfite; N-bromoacetamide / dichloromethane; water; acetone; tert-butyl alcohol
3: sodium carbonate / tetrahydrofuran; chloroform; water
4: sodium carbonate; sodium hydrogensulfite; bunazosin / 1,4-dioxane; water; benzene
With
perchloric acid; p-toluenesulfonic acid monohydrate; potassium acetate; sodium carbonate; sodium hydrogensulfite; bunazosin; trifluoroacetic anhydride; sodium sulfite; N-bromoacetamide;
In
tetrahydrofuran; 1,4-dioxane; methanol; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; dichloromethane; chloroform; water; acetic acid; acetone; tert-butyl alcohol; benzene;
