5-chloro-4-(5-chloro-6-(3,3-difluoropyrrolidin-1-yl)pyridin-3-yloxy)-2-fluoro-N-(methylsulfonyl)benzamide

Base Information

Chemical Name:5-chloro-4-(5-chloro-6-(3,3-difluoropyrrolidin-1-yl)pyridin-3-yloxy)-2-fluoro-N-(methylsulfonyl)benzamide
CAS No.:1355064-60-6
Molecular Formula:C₁₇H₁₄Cl₂F₃N₃O₄S
Molecular Weight:484.283
Hs Code.:

Synonyms:5-chloro-4-(5-chloro-6-(3,3-difluoropyrrolidin-1-yl)pyridin-3-yloxy)-2-fluoro-N-(methylsulfonyl)benzamide

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Chemical Property of 5-chloro-4-(5-chloro-6-(3,3-difluoropyrrolidin-1-yl)pyridin-3-yloxy)-2-fluoro-N-(methylsulfonyl)benzamide

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Technology Process of 5-chloro-4-(5-chloro-6-(3,3-difluoropyrrolidin-1-yl)pyridin-3-yloxy)-2-fluoro-N-(methylsulfonyl)benzamide

There total 2 articles about 5-chloro-4-(5-chloro-6-(3,3-difluoropyrrolidin-1-yl)pyridin-3-yloxy)-2-fluoro-N-(methylsulfonyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 1355063-64-7
5-chloro-4-[(5-chloro-6-fluoropyridin-3-yl)oxy]-2-fluoro-N-(methylsulfonyl)benzamide

: 163457-23-6
3,3-difluoropyrrolidine hydrochloride

: 1355064-60-6
5-chloro-4-(5-chloro-6-(3,3-difluoropyrrolidin-1-yl)pyridin-3-yloxy)-2-fluoro-N-(methylsulfonyl)benzamide

Guidance literature:: With triethylamine; In dimethyl sulfoxide; at 80 ℃; for 120h;

Reference yield:

: 1355069-01-0
5-Chloro-4-(5-chloro-6-fluoropyridin-3-yloxy)-2-fluorobenzoic acid

: 1355064-60-6
5-chloro-4-(5-chloro-6-(3,3-difluoropyrrolidin-1-yl)pyridin-3-yloxy)-2-fluoro-N-(methylsulfonyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 18 h / 20 °C

2: triethylamine / dimethyl sulfoxide / 120 h / 80 °C

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; dimethyl sulfoxide;