1,1,1,3,3,3-hexafluoro-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propan-2-ol

Base Information

Chemical Name:1,1,1,3,3,3-hexafluoro-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propan-2-ol
CAS No.:449804-09-5
Molecular Formula:C₁₅H₁₇BF₆O₃
Molecular Weight:370.1
Hs Code.:

Synonyms:1,1,1,3,3,3-hexafluoro-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propan-2-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1,1,1,3,3,3-hexafluoro-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propan-2-ol

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of 1,1,1,3,3,3-hexafluoro-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propan-2-ol

There total 3 articles about 1,1,1,3,3,3-hexafluoro-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 2402-72-4
2-(4-bromophenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

: 73183-34-3
bis(pinacol)diborane

: 449804-09-5
1,1,1,3,3,3-hexafluoro-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propan-2-ol

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.10.020

Reference yield: 45.0%

: 1214788-34-7
1,1,1,3,3,3-hexafluoro-2-(4-iodophenyl)propan-2-ol

: 73183-34-3
bis(pinacol)diborane

: 449804-09-5
1,1,1,3,3,3-hexafluoro-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propan-2-ol

Guidance literature:: With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate; In 1,4-dioxane; at 90 ℃; Inert atmosphere;

Reference yield:

: 722-92-9
2-(4-aminophenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

: 449804-09-5
1,1,1,3,3,3-hexafluoro-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium nitrite; hydrogenchloride / N,N-dimethyl-formamide; water / 0.5 h / 0 - 5 °C

1.2: 0 - 20 °C

2.1: potassium acetate; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 16 h / 80 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; potassium acetate; sodium nitrite; In water; N,N-dimethyl-formamide;