2-Amino-4-phenyl-5-(phenylsulfonyl)thiophene-3-carbonitrile

Base Information

• Chemical Name: 2-Amino-4-phenyl-5-(phenylsulfonyl)thiophene-3-carbonitrile
• CAS No.: 197861-63-5
• Molecular Formula: C₁₇H₁₂N₂O₂S₂
• Molecular Weight: 340.426
• Mol file: 197861-63-5.mol

Synonyms:2-Amino-4-phenyl-5-(phenylsulfonyl)thiophene-3-carbonitrile

Chemical Property of 2-Amino-4-phenyl-5-(phenylsulfonyl)thiophene-3-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Amino-4-phenyl-5-(phenylsulfonyl)thiophene-3-carbonitrile

There total 4 articles about 2-Amino-4-phenyl-5-(phenylsulfonyl)thiophene-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

2-(phenylsulfonyl)acetophenone (3406-03-9) + malononitrile (109-77-3) → 2-Amino-4-phenyl-5-(phenylsulfonyl)thiophene-3-carbonitrile (197861-63-5)

Guidance literature:

With sulfur; triethylamine; In N,N-dimethyl-formamide; for 6h; Heating;

DOI:10.1007/BF00807600

Reference yield: 55.0%

1,1-Dicyano-2-phenyl-3-(phenylsulfonyl)propene (136289-43-5) → 2-Amino-4-phenyl-5-(phenylsulfonyl)thiophene-3-carbonitrile (197861-63-5)

Guidance literature:

With sulfur; In 1,4-dioxane; for 0.5h; Heating;

Reference yield:

2-(1-phenylethylidene)propanedinitrile (5447-87-0) → 2-Amino-4-phenyl-5-(phenylsulfonyl)thiophene-3-carbonitrile (197861-63-5)

Guidance literature:

Multi-step reaction with 3 steps

1: NBS; benzoyl peroxide / CCl₄ / 2 h / Heating

2: ethanol / 2 h / Heating

3: 55 percent / S₈ / dioxane / 0.5 h / Heating

With sulfur; N-Bromosuccinimide; dibenzoyl peroxide; In 1,4-dioxane; tetrachloromethane; ethanol; 1: Bromination / 2: Alkylation / 3: Cyclization;

DOI:10.1515/znb-2000-0119

upstream raw materials:

2-(phenylsulfonyl)acetophenone

malononitrile

1,1-Dicyano-2-phenyl-3-(phenylsulfonyl)propene

2-(1-phenylethylidene)propanedinitrile

Downstream raw materials:

2-Amino-5-benzenesulfonyl-N-hydroxy-4-phenyl-thiophene-3-carboxamidine

5-Benzenesulfonyl-4-phenyl-1H-thieno[2,3-c]pyrazol-3-ylamine