5-Benzenesulfonyl-4-phenyl-1H-thieno[2,3-c]pyrazol-3-ylamine

Base Information

• Chemical Name: 5-Benzenesulfonyl-4-phenyl-1H-thieno[2,3-c]pyrazol-3-ylamine
• CAS No.: 197861-67-9
• Molecular Formula: C₁₇H₁₃N₃O₂S₂
• Molecular Weight: 355.441
• Mol file: 197861-67-9.mol

Synonyms:5-Benzenesulfonyl-4-phenyl-1H-thieno[2,3-c]pyrazol-3-ylamine

Chemical Property of 5-Benzenesulfonyl-4-phenyl-1H-thieno[2,3-c]pyrazol-3-ylamine

Chemical Property:

Purity/Quality:

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Technology Process of 5-Benzenesulfonyl-4-phenyl-1H-thieno[2,3-c]pyrazol-3-ylamine

There total 3 articles about 5-Benzenesulfonyl-4-phenyl-1H-thieno[2,3-c]pyrazol-3-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

2-Amino-5-benzenesulfonyl-N-hydroxy-4-phenyl-thiophene-3-carboxamidine (197861-66-8) → 5-Benzenesulfonyl-4-phenyl-1H-thieno[2,3-c]pyrazol-3-ylamine (197861-67-9)

Guidance literature:

In pyridine; for 5h; Heating;

DOI:10.1007/BF00807600

Reference yield: 59.0%

2-Amino-4-phenyl-5-(phenylsulfonyl)thiophene-3-carbonitrile (197861-63-5) → 5-Benzenesulfonyl-4-phenyl-1H-thieno[2,3-c]pyrazol-3-ylamine (197861-67-9)

Guidance literature:

With hydroxylamine hydrochloride; sodium acetate; In acetic acid; for 6h; Heating;

DOI:10.1007/BF00807600

Reference yield:

2-(phenylsulfonyl)acetophenone (3406-03-9) → 5-Benzenesulfonyl-4-phenyl-1H-thieno[2,3-c]pyrazol-3-ylamine (197861-67-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent / sulfur, Et₃N / dimethylformamide / 6 h / Heating

2: 59 percent / NH₂OH*HCl, AcONa / acetic acid / 6 h / Heating

With hydroxylamine hydrochloride; sodium acetate; sulfur; triethylamine; In acetic acid; N,N-dimethyl-formamide;

DOI:10.1007/BF00807600

upstream raw materials:

2-Amino-4-phenyl-5-(phenylsulfonyl)thiophene-3-carbonitrile

2-Amino-5-benzenesulfonyl-N-hydroxy-4-phenyl-thiophene-3-carboxamidine

2-(phenylsulfonyl)acetophenone