N,N′-(2-nitrobenzenesulfonamide)-N,N″-[[6-(methoxycarbonyl)-pyridin-2-yl]methyl]-1-(p-nitrobenzyl)-1,2-diaminoethane

Base Information

• Chemical Name: N,N′-(2-nitrobenzenesulfonamide)-N,N″-[[6-(methoxycarbonyl)-pyridin-2-yl]methyl]-1-(p-nitrobenzyl)-1,2-diaminoethane
• CAS No.: 1502873-74-6
• Molecular Formula: C₃₇H₃₃N₇O₁₄S₂
• Molecular Weight: 863.84
• Mol file: 1502873-74-6.mol

Synonyms:N,N′-(2-nitrobenzenesulfonamide)-N,N″-[[6-(methoxycarbonyl)-pyridin-2-yl]methyl]-1-(p-nitrobenzyl)-1,2-diaminoethane

Chemical Property of N,N′-(2-nitrobenzenesulfonamide)-N,N″-[[6-(methoxycarbonyl)-pyridin-2-yl]methyl]-1-(p-nitrobenzyl)-1,2-diaminoethane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,N′-(2-nitrobenzenesulfonamide)-N,N″-[[6-(methoxycarbonyl)-pyridin-2-yl]methyl]-1-(p-nitrobenzyl)-1,2-diaminoethane

There total 2 articles about N,N′-(2-nitrobenzenesulfonamide)-N,N″-[[6-(methoxycarbonyl)-pyridin-2-yl]methyl]-1-(p-nitrobenzyl)-1,2-diaminoethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

N,N′-(2-nitrobenzenesulfonamide)-1-(p-nitrobenzyl)-1,2-diaminoethane (1450624-93-7) + methyl 6-(bromomethyl)picolinate (146462-25-1) → N,N′-(2-nitrobenzenesulfonamide)-N,N″-[[6-(methoxycarbonyl)-pyridin-2-yl]methyl]-1-(p-nitrobenzyl)-1,2-diaminoethane (1502873-74-6)

Guidance literature:

With sodium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 48h;

DOI:10.1039/c3dt51940f

Reference yield:

1-(p-nitrobenzyl)ethylenediamine + 2-Nitrobenzenesulfonyl chloride (1694-92-4) → N,N′-(2-nitrobenzenesulfonamide)-N,N″-[[6-(methoxycarbonyl)-pyridin-2-yl]methyl]-1-(p-nitrobenzyl)-1,2-diaminoethane (1502873-74-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / tetrahydrofuran / 24 h / 20 °C

2: sodium carbonate / N,N-dimethyl-formamide / 48 h / 60 °C

With sodium hydrogencarbonate; sodium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1039/c3dt51940f

Reference yield: 90.0%

N,N′-(2-nitrobenzenesulfonamide)-N,N″-[[6-(methoxycarbonyl)-pyridin-2-yl]methyl]-1-(p-nitrobenzyl)-1,2-diaminoethane (1502873-74-6) → 2-(p-nitrobenzyl)-(1,2-bis[N,N'-{p-nitrobenzyl}methyl]-N,N'-bis-[6-carboxy-2-pyridylmethyl])ethylenediamine (1255535-34-2)

Guidance literature:

With potassium carbonate; thiophenol; In tetrahydrofuran; at 20 ℃; for 72h;

DOI:10.1039/c3dt51940f

upstream raw materials:

2-Nitrobenzenesulfonyl chloride

N,N′-(2-nitrobenzenesulfonamide)-1-(p-nitrobenzyl)-1,2-diaminoethane

methyl 6-(bromomethyl)picolinate

Downstream raw materials:

2-(p-nitrobenzyl)-(1,2-bis[N,N'-{p-nitrobenzyl}methyl]-N,N'-bis-[6-carboxy-2-pyridylmethyl])ethylenediamine

N,N′-[methylphosphonate]-N,N′-[((6-carboxylato)pyridin-2-yl)-methyl]-1-(p-nitrobenzyl)-1,2-diaminoethane

N,N'-(methylphosphonate)-N,N'-[((6-carboxylato)pyridin-2-yl)methyl]-1-(p-benzyl-isothiocyanato)-1,2-diaminoethane