2-(p-nitrobenzyl)-(1,2-bis[N,N'-{p-nitrobenzyl}methyl]-N,N'-bis-[6-carboxy-2-pyridylmethyl])ethylenediamine

Base Information

• Chemical Name: 2-(p-nitrobenzyl)-(1,2-bis[N,N'-{p-nitrobenzyl}methyl]-N,N'-bis-[6-carboxy-2-pyridylmethyl])ethylenediamine
• CAS No.: 1255535-34-2
• Molecular Formula: C₂₃H₂₃N₅O₆
• Molecular Weight: 465.466
• Mol file: 1255535-34-2.mol

Synonyms:2-(p-nitrobenzyl)-(1,2-bis[N,N'-{p-nitrobenzyl}methyl]-N,N'-bis-[6-carboxy-2-pyridylmethyl])ethylenediamine

Chemical Property of 2-(p-nitrobenzyl)-(1,2-bis[N,N'-{p-nitrobenzyl}methyl]-N,N'-bis-[6-carboxy-2-pyridylmethyl])ethylenediamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(p-nitrobenzyl)-(1,2-bis[N,N'-{p-nitrobenzyl}methyl]-N,N'-bis-[6-carboxy-2-pyridylmethyl])ethylenediamine

There total 4 articles about 2-(p-nitrobenzyl)-(1,2-bis[N,N'-{p-nitrobenzyl}methyl]-N,N'-bis-[6-carboxy-2-pyridylmethyl])ethylenediamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N,N′-(2-nitrobenzenesulfonamide)-N,N″-[[6-(methoxycarbonyl)-pyridin-2-yl]methyl]-1-(p-nitrobenzyl)-1,2-diaminoethane (1502873-74-6) → 2-(p-nitrobenzyl)-(1,2-bis[N,N'-{p-nitrobenzyl}methyl]-N,N'-bis-[6-carboxy-2-pyridylmethyl])ethylenediamine (1255535-34-2)

Guidance literature:

With potassium carbonate; thiophenol; In tetrahydrofuran; at 20 ℃; for 72h;

DOI:10.1039/c3dt51940f

Reference yield: 83.0%

(2-(p-nitrobenzyl)-N,N'-[6-{methoxycarbonyl}pyridin-2-yl]methylamino)ethane (1255535-33-1) → 2-(p-nitrobenzyl)-(1,2-bis[N,N'-{p-nitrobenzyl}methyl]-N,N'-bis-[6-carboxy-2-pyridylmethyl])ethylenediamine (1255535-34-2)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; for 0.5h;

DOI:10.1021/ja106399h

Reference yield:

1-(p-nitrobenzyl)ethylenediamine → 2-(p-nitrobenzyl)-(1,2-bis[N,N'-{p-nitrobenzyl}methyl]-N,N'-bis-[6-carboxy-2-pyridylmethyl])ethylenediamine (1255535-34-2)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / tetrahydrofuran / 24 h / 20 °C

2: sodium carbonate / N,N-dimethyl-formamide / 48 h / 60 °C

3: potassium carbonate; thiophenol / tetrahydrofuran / 72 h / 20 °C

With sodium hydrogencarbonate; sodium carbonate; potassium carbonate; thiophenol; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1039/c3dt51940f

upstream raw materials:

(2-(p-nitrobenzyl)-N,N'-[6-{methoxycarbonyl}pyridin-2-yl]methylamino)ethane

N,N′-(2-nitrobenzenesulfonamide)-1-(p-nitrobenzyl)-1,2-diaminoethane

N,N′-(2-nitrobenzenesulfonamide)-N,N″-[[6-(methoxycarbonyl)-pyridin-2-yl]methyl]-1-(p-nitrobenzyl)-1,2-diaminoethane

Downstream raw materials:

N,N′-[methylphosphonate]-N,N′-[((6-carboxylato)pyridin-2-yl)-methyl]-1-(p-nitrobenzyl)-1,2-diaminoethane