4-<<6-(2-cyclopentylethoxy)-3-<2-(methoxycarbonyl)ethyl>indol-1-yl>methyl>-3-methoxybenzoic acid

Base Information

Chemical Name:4-<<6-(2-cyclopentylethoxy)-3-<2-(methoxycarbonyl)ethyl>indol-1-yl>methyl>-3-methoxybenzoic acid
CAS No.:142535-31-7
Molecular Formula:C₂₈H₃₃NO₆
Molecular Weight:479.573
Hs Code.:

Synonyms:4-<<6-(2-cyclopentylethoxy)-3-<2-(methoxycarbonyl)ethyl>indol-1-yl>methyl>-3-methoxybenzoic acid

Suppliers and Price of 4-<<6-(2-cyclopentylethoxy)-3-<2-(methoxycarbonyl)ethyl>indol-1-yl>methyl>-3-methoxybenzoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-<<6-(2-cyclopentylethoxy)-3-<2-(methoxycarbonyl)ethyl>indol-1-yl>methyl>-3-methoxybenzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-<<6-(2-cyclopentylethoxy)-3-<2-(methoxycarbonyl)ethyl>indol-1-yl>methyl>-3-methoxybenzoic acid

There total 9 articles about 4-<<6-(2-cyclopentylethoxy)-3-<2-(methoxycarbonyl)ethyl>indol-1-yl>methyl>-3-methoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 142535-30-6
(E)-4-<<6-(2-cyclopentylethoxy)-3-<2-(methoxycarbonyl)ethylidenyl>indol-1-yl>methyl>-3-methoxybenzoic acid

: 142535-31-7
4-<<6-(2-cyclopentylethoxy)-3-<2-(methoxycarbonyl)ethyl>indol-1-yl>methyl>-3-methoxybenzoic acid

Guidance literature:: With potassium hydroxide; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; for 3h; under 2585.7 Torr;
DOI:10.1021/jm00091a010

Reference yield:

: 2380-86-1
6-hydroxy-1H-indole

: 142535-31-7
4-<<6-(2-cyclopentylethoxy)-3-<2-(methoxycarbonyl)ethyl>indol-1-yl>methyl>-3-methoxybenzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 75 percent / Ph₃P, diethyl azodicarboxylate / tetrahydrofuran

2: 1.) POCl₃, 2.) aq. NaOH / 1.) 0 deg C, 30 min, 2.) RT, 1 h, 3.) reflux, 5 min

3: 54 percent / K₂CO₃ / dimethylformamide / 72 h

4: 84 percent / dioxane / 48 h / Heating

5: 53 percent / Et₃N, trimethylsilyl trifluoromethanesulfonate / dioxane / 24 h / Ambient temperature

6: 59 percent / H₂, 6 M aq. KOH / 10percent Pd/C / methanol; tetrahydrofuran / 3 h / 2585.7 Torr

With potassium hydroxide; sodium hydroxide; trimethylsilyl trifluoromethanesulfonate; hydrogen; potassium carbonate; triethylamine; triphenylphosphine; diethylazodicarboxylate; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00091a010

Reference yield:

: 766-00-7
2-cyclopentyl-ethanol

: 142535-31-7
4-<<6-(2-cyclopentylethoxy)-3-<2-(methoxycarbonyl)ethyl>indol-1-yl>methyl>-3-methoxybenzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 75 percent / Ph₃P, diethyl azodicarboxylate / tetrahydrofuran

2: 1.) POCl₃, 2.) aq. NaOH / 1.) 0 deg C, 30 min, 2.) RT, 1 h, 3.) reflux, 5 min

3: 54 percent / K₂CO₃ / dimethylformamide / 72 h

4: 84 percent / dioxane / 48 h / Heating

5: 53 percent / Et₃N, trimethylsilyl trifluoromethanesulfonate / dioxane / 24 h / Ambient temperature

6: 59 percent / H₂, 6 M aq. KOH / 10percent Pd/C / methanol; tetrahydrofuran / 3 h / 2585.7 Torr

With potassium hydroxide; sodium hydroxide; trimethylsilyl trifluoromethanesulfonate; hydrogen; potassium carbonate; triethylamine; triphenylphosphine; diethylazodicarboxylate; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00091a010