2380-86-1

Basic information

• Product Name: 6-Hydroxyindole
• Synonyms: 1H-INDOL-6-OL;6-INDOLOL;6-HYDROXYINDOLE;INDOLOL;5.7-dichloroindole 2380-86-1;6-Hydroyindole;Indolol，6-Hydroxyindole;6-Hydroxyindole ,98%
• CAS NO: 2380-86-1
• Molecular Formula: C₈H₇NO
• Molecular Weight: 133.15
• EINECS: 417-020-4
• Product Categories: blocks;IndolesOxindoles;Indoles and derivatives;Heterocycles series;Indoline & Oxindole;Indoles;Indole;Heterocycle-Indole series
• Mol File: 2380-86-1.mol
• Article Data: 6

Chemical Properties

• Melting Point: 124-130 °C
• Boiling Point: 343.2 °C at 760 mmHg
• Flash Point: 161.4 °C
• Appearance: White to off-white/Shiny Crystalline Powder
• Density: 1.327 g/cm³
• Vapor Pressure: 0.000369mmHg at 25°C
• Refractive Index: 1.694
• Storage Temp.: Keep Cold
• PKA: 10.07±0.40(Predicted)
• CAS DataBase Reference: 6-Hydroxyindole(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Hydroxyindole(2380-86-1)
• EPA Substance Registry System: 6-Hydroxyindole(2380-86-1)

Safety Data

• Hazard Codes: Xi,N,Xn
• Statements: 36/37/38-51/53-43-41-22
• Safety Statements: 37/39-26-61-24-2
• RIDADR: UN 3077
• WGK Germany: 3
• HazardClass: IRRITANT, KEEP COLD
• PackingGroup: Ⅲ
• Hazardous Substances Data: 2380-86-1(Hazardous Substances Data)

Usage

Chemical Properties

White to off-white shiny crystalline powder

Uses

Reactant for preparation of tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles as potential anticancer immunomodulatorsReactant for asymmetrical synthesis of notoamide J as a potential biosynthetic precursor of prenylated indole alkaloidsReactant for preparation of (quinolinyloxymethyl)isoxazolecarboxylate esters antituberculosis agentsReactant for preparation of indolyl(propanolamine) derivatives as HIV inhibitorsReactant for preparation of indoleoxyacetic acid derivatives as peroxisome proliferator-activated receptor agonistsReactant for preparation of 1-aroylindole 3-aroylindoles combretastatin A-4 analogs as antitumor agents and tubulin polymerization inhibitors

InChI:InChI=1/C8H5Cl2N/c9-6-3-5-1-2-11-8(5)7(10)4-6/h1-4,11H

Upstream product

• 120-72-9 indole 
• 153805-86-8 3-Benzyloxy-6-(2-pyrrolidinylvinyl)nitrobenzene 
• 99474-13-2 (E)-5-(benzyloxy)-2-<2-(dimethylamino)vinyl>nitrobenzene 

Downstream Products

• 158862-62-5 6-(3-pyridinylmethoxy)indole 
• 4770-37-0 6-hydroxy-indoline 
• 1195738-12-5 3,3'-((4-nitrophenyl)methylene)bis(6-bromo-1H-indole) 

Relevant articles and documents

Development of large-scale preparations of indole derivatives: Evaluation of potential thermal hazards and studies of reaction kinetics and mechanisms

Hydrogenation of (E)-2-nitropyrrolidinostyrene in the presence of the doped rhodium catalyst is safe, scalable, and highly effective for the preparation of 6-benzyloxyindole. Reaction kinetics with/without additives also were examined using in situ IR for

PROCESS FOR PRODUCING INDOLOPYRROLOCARBAZOLE DERIVATIVE

The present invention provides a process for industrially advantageously producing a compound represented by the formula (I): or a pharmaceutically acceptable salt thereof, which is useful as an anticancer agent, and also provides a catalyst used for hydrogenation reaction in the process.

HYDROXYLATION OF INDOLINES AND INDOLES BY HYDROGEN PEROXIDE IN SUPERACIDS

In SbF5-HF, indolines and indoles are hydroxylated on the aromatic ring, protonated hydrogen peroxide H3O2+ reacting on the protonated substrates.