Technology Process of 3-[1-acetyl-5-(4-methyl-cyclohexyl)-1,2,3,6-tetrahydro-pyridin-4-yl]-5-phenyl-thiophene-2-carboxylic acid
There total 9 articles about 3-[1-acetyl-5-(4-methyl-cyclohexyl)-1,2,3,6-tetrahydro-pyridin-4-yl]-5-phenyl-thiophene-2-carboxylic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
methyl 3-(5-(4-methylcyclohexyl)-1,2,3,6-tetrahydropyridin-4-yl)-5-phenylthiophene-2-carboxylate; acetyl chloride;
With
triethylamine;
In
dichloromethane;
at 20 ℃;
With
sodium hydroxide;
In
methanol;
at 0 - 20 ℃;
for 4h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: diiodomethane; tert.-butylnitrite / acetonitrile / 1.5 h
2.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide; water / 3 h / 88 °C / Inert atmosphere
3.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide; water / 3 h / 88 °C / Inert atmosphere
4.1: hydrogen / palladium 10% on activated carbon / methanol / 2585.81 Torr
5.1: benzyl bromide / acetonitrile / 3 h / 80 °C
5.2: 80 °C
6.1: triethylamine / dichloromethane / 20 °C
6.2: 4 h / 0 - 20 °C
With
tert.-butylnitrite; diiodomethane; hydrogen; benzyl bromide; sodium carbonate; triethylamine;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon;
In
methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium hexamethyldisilazane / tetrahydrofuran / 8 h / -78 °C / Inert atmosphere
2.1: potassium acetate / 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 90 °C / Inert atmosphere
3.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide; water / 3 h / 88 °C / Inert atmosphere
4.1: hydrogen / palladium 10% on activated carbon / methanol / 2585.81 Torr
5.1: benzyl bromide / acetonitrile / 3 h / 80 °C
5.2: 80 °C
6.1: triethylamine / dichloromethane / 20 °C
6.2: 4 h / 0 - 20 °C
With
hydrogen; potassium acetate; sodium hexamethyldisilazane; benzyl bromide; sodium carbonate; triethylamine;
1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
