4-tert-butyl 2-ethyl 3-amino-1-(2-bromo-5-fluorobenzyl)-5-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-1H-pyrrole-2,4-dicarboxylate

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Chemical Name:4-tert-butyl 2-ethyl 3-amino-1-(2-bromo-5-fluorobenzyl)-5-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-1H-pyrrole-2,4-dicarboxylate
CAS No.:1338930-83-8
Molecular Formula:C₂₉H₄₀BrFN₄O₆
Molecular Weight:639.562
Hs Code.:

Synonyms:4-tert-butyl 2-ethyl 3-amino-1-(2-bromo-5-fluorobenzyl)-5-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-1H-pyrrole-2,4-dicarboxylate

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Chemical Property of 4-tert-butyl 2-ethyl 3-amino-1-(2-bromo-5-fluorobenzyl)-5-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-1H-pyrrole-2,4-dicarboxylate

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Technology Process of 4-tert-butyl 2-ethyl 3-amino-1-(2-bromo-5-fluorobenzyl)-5-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-1H-pyrrole-2,4-dicarboxylate

There total 4 articles about 4-tert-butyl 2-ethyl 3-amino-1-(2-bromo-5-fluorobenzyl)-5-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-1H-pyrrole-2,4-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₉H₄₀BrFN₄O₆

: 75-65-0
tert-butyl alcohol

: 1338930-83-8
4-tert-butyl 2-ethyl 3-amino-1-(2-bromo-5-fluorobenzyl)-5-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-1H-pyrrole-2,4-dicarboxylate

: C₃₁H₄₄BrFN₄O₆

Guidance literature:: tert-butyl alcohol; With lithium amide; at 80 ℃; for 1h; Inert atmosphere;

C₂₉H₄₀BrFN₄O₆; In toluene; acetonitrile; at 30 ℃; for 2h; Inert atmosphere;

With ammonium chloride; In water; ethyl acetate; Inert atmosphere; Saturated solution;
DOI:10.1016/j.bmc.2011.07.042

Reference yield:

: 747392-34-3
1-(2-bromo-5-fluorophenyl)methanamine

: 1338930-83-8
4-tert-butyl 2-ethyl 3-amino-1-(2-bromo-5-fluorobenzyl)-5-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-1H-pyrrole-2,4-dicarboxylate

: C₃₁H₄₄BrFN₄O₆

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetonitrile / 1 h / 50 °C / Inert atmosphere

1.2: 10 h / 80 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 50 °C / Inert atmosphere

3.1: lithium amide / 1 h / 80 °C / Inert atmosphere

3.2: 2 h / 30 °C / Inert atmosphere

3.3: Inert atmosphere; Saturated solution

With lithium amide; potassium carbonate; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2011.07.042

Reference yield:

: C₂₅H₃₄BrFN₄O₄

: 1338930-83-8
4-tert-butyl 2-ethyl 3-amino-1-(2-bromo-5-fluorobenzyl)-5-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-1H-pyrrole-2,4-dicarboxylate

: C₃₁H₄₄BrFN₄O₆

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 50 °C / Inert atmosphere

2.1: lithium amide / 1 h / 80 °C / Inert atmosphere

2.2: 2 h / 30 °C / Inert atmosphere

2.3: Inert atmosphere; Saturated solution

With lithium amide; potassium carbonate; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.07.042