(2S)-2-amino-N-[2-(3,4-dimethoxyphenyl)ethyl]-3-phenylpropanamide

Base Information

• Chemical Name: (2S)-2-amino-N-[2-(3,4-dimethoxyphenyl)ethyl]-3-phenylpropanamide
• CAS No.: 603121-72-8
• Molecular Formula: C₁₉H₂₄N₂O₃
• Molecular Weight: 328.411
• Mol file: 603121-72-8.mol

Synonyms:(2S)-2-amino-N-[2-(3,4-dimethoxyphenyl)ethyl]-3-phenylpropanamide

Chemical Property of (2S)-2-amino-N-[2-(3,4-dimethoxyphenyl)ethyl]-3-phenylpropanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S)-2-amino-N-[2-(3,4-dimethoxyphenyl)ethyl]-3-phenylpropanamide

There total 6 articles about (2S)-2-amino-N-[2-(3,4-dimethoxyphenyl)ethyl]-3-phenylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

benzyl (1S)-1-benzyl-2-{[2-(3,4-dimethoxyphenyl)ethyl]amino}-2-oxoethylcarbamate (143439-64-9) → (2S)-2-amino-N-[2-(3,4-dimethoxyphenyl)ethyl]-3-phenylpropanamide (603121-72-8)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; water; at 50 ℃; for 2h;

DOI:10.1002/ejoc.200200705

Reference yield: 89.3%

2-(boc)amino-N-[2-(3,4-dimethoxy-phenyl)-ethyl]-3-phenyl-propionamide (1064655-76-0) → (2S)-2-amino-N-[2-(3,4-dimethoxyphenyl)ethyl]-3-phenylpropanamide (603121-72-8)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h; Cooling with ice;

Reference yield:

N-Cbz-L-Phe (1161-13-3) → (2S)-2-amino-N-[2-(3,4-dimethoxyphenyl)ethyl]-3-phenylpropanamide (603121-72-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / Et₃N; BOP / tetrahydrofuran / 20 °C

2: 97 percent / HCl; H₂ / Pd/C / ethanol; H₂O / 2 h / 50 °C

With hydrogenchloride; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; water;

DOI:10.1002/ejoc.200200705

upstream raw materials:

benzyl (1S)-1-benzyl-2-{[2-(3,4-dimethoxyphenyl)ethyl]amino}-2-oxoethylcarbamate

N-Cbz-L-Phe

2-(3,4-dimethoxyphenyl)-ethylamine

2-(boc)amino-N-[2-(3,4-dimethoxy-phenyl)-ethyl]-3-phenyl-propionamide

Downstream raw materials:

2-amino-N-[2-(3,4-dihydroxy-phenyl)-ethyl]-3-phenyl-propionamide