triethyl 10-<4-(4-methoxyphenylsulfonamido)butylcarbamoylmethyl>-1,4,7,10-tetraazacyclododecane-1,4,7-triyltrimethylenetri(methylphosphinate)

Base Information

• Chemical Name: triethyl 10-<4-(4-methoxyphenylsulfonamido)butylcarbamoylmethyl>-1,4,7,10-tetraazacyclododecane-1,4,7-triyltrimethylenetri(methylphosphinate)
• CAS No.: 148932-59-6
• Molecular Formula: C₃₃H₆₅N₆O₁₀P₃S
• Molecular Weight: 830.901
• Mol file: 148932-59-6.mol

Synonyms:triethyl 10-<4-(4-methoxyphenylsulfonamido)butylcarbamoylmethyl>-1,4,7,10-tetraazacyclododecane-1,4,7-triyltrimethylenetri(methylphosphinate)

Chemical Property of triethyl 10-<4-(4-methoxyphenylsulfonamido)butylcarbamoylmethyl>-1,4,7,10-tetraazacyclododecane-1,4,7-triyltrimethylenetri(methylphosphinate)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of triethyl 10-<4-(4-methoxyphenylsulfonamido)butylcarbamoylmethyl>-1,4,7,10-tetraazacyclododecane-1,4,7-triyltrimethylenetri(methylphosphinate)

There total 4 articles about triethyl 10-<4-(4-methoxyphenylsulfonamido)butylcarbamoylmethyl>-1,4,7,10-tetraazacyclododecane-1,4,7-triyltrimethylenetri(methylphosphinate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + methyldiethoxyphosphine (15715-41-0) + <4-(4-methoxyphenylsulfonamido)butylcarbamoylmethyl>-1,4,7,10-tetraazacyclododecane (148932-53-0) → triethyl 10-<4-(4-methoxyphenylsulfonamido)butylcarbamoylmethyl>-1,4,7,10-tetraazacyclododecane-1,4,7-triyltrimethylenetri(methylphosphinate) (148932-59-6)

Guidance literature:

With 4 A molecular sieve; In tetrahydrofuran; at 100 ℃; for 18h;

Reference yield:

N-(4-bromoacetamidobutyl)-4-methoxybenzenesulfonamide (148932-52-9) → triethyl 10-<4-(4-methoxyphenylsulfonamido)butylcarbamoylmethyl>-1,4,7,10-tetraazacyclododecane-1,4,7-triyltrimethylenetri(methylphosphinate) (148932-59-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) Mo(CO)6, 2.) K₂CO₃, 3.) 10percent aq. HCl, air

2: 82 percent / 4 Angstroem molecular sieves / tetrahydrofuran / 18 h / 100 °C

With hydrogenchloride; air; hexacarbonyl molybdenum; 4 A molecular sieve; potassium carbonate; In tetrahydrofuran;

Reference yield:

N-(4-aminobutyl)-4-methoxybenzenesulfonamide hydrochloride → triethyl 10-<4-(4-methoxyphenylsulfonamido)butylcarbamoylmethyl>-1,4,7,10-tetraazacyclododecane-1,4,7-triyltrimethylenetri(methylphosphinate) (148932-59-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 36 percent / aq. NaOH / 1,2-dichloro-ethane / 1.) -10 deg C, 1 h, 2.) RT, overnight

2: 1.) Mo(CO)6, 2.) K₂CO₃, 3.) 10percent aq. HCl, air

3: 82 percent / 4 Angstroem molecular sieves / tetrahydrofuran / 18 h / 100 °C

With hydrogenchloride; sodium hydroxide; air; hexacarbonyl molybdenum; 4 A molecular sieve; potassium carbonate; In tetrahydrofuran; 1,2-dichloro-ethane;

upstream raw materials:

formaldehyd

methyldiethoxyphosphine

<4-(4-methoxyphenylsulfonamido)butylcarbamoylmethyl>-1,4,7,10-tetraazacyclododecane

N-(4-bromoacetamidobutyl)-4-methoxybenzenesulfonamide

Downstream raw materials:

10-<4-(4-methoxyphenylsulfonamido)butylcarbamoylmethyl>-1,4,7,10-tetraazacyclododecane-1,4,7-triyltrimethylenetri(methylphosphinic acid)