2,3-dihydro-thieno[3,4-b][1,4]dioxine-5-carboxylic acid [(1R,3S,4S)-2-(2-methyl-5-m-tolyl-thiazole-4-carbonyl)-2-aza-bicyclo[2.2.1]hept-3-ylmethyl]-amide

Base Information

Chemical Name:2,3-dihydro-thieno[3,4-b][1,4]dioxine-5-carboxylic acid [(1R,3S,4S)-2-(2-methyl-5-m-tolyl-thiazole-4-carbonyl)-2-aza-bicyclo[2.2.1]hept-3-ylmethyl]-amide
CAS No.:1181571-64-1
Molecular Formula:C₂₆H₂₇N₃O₄S₂
Molecular Weight:509.65
Hs Code.:

Synonyms:2,3-dihydro-thieno[3,4-b][1,4]dioxine-5-carboxylic acid [(1R,3S,4S)-2-(2-methyl-5-m-tolyl-thiazole-4-carbonyl)-2-aza-bicyclo[2.2.1]hept-3-ylmethyl]-amide

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Chemical Property of 2,3-dihydro-thieno[3,4-b][1,4]dioxine-5-carboxylic acid [(1R,3S,4S)-2-(2-methyl-5-m-tolyl-thiazole-4-carbonyl)-2-aza-bicyclo[2.2.1]hept-3-ylmethyl]-amide

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Technology Process of 2,3-dihydro-thieno[3,4-b][1,4]dioxine-5-carboxylic acid [(1R,3S,4S)-2-(2-methyl-5-m-tolyl-thiazole-4-carbonyl)-2-aza-bicyclo[2.2.1]hept-3-ylmethyl]-amide

There total 6 articles about 2,3-dihydro-thieno[3,4-b][1,4]dioxine-5-carboxylic acid [(1R,3S,4S)-2-(2-methyl-5-m-tolyl-thiazole-4-carbonyl)-2-aza-bicyclo[2.2.1]hept-3-ylmethyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 260063-21-6
2,3-dihydrothieno[3,4-b][1,4]dioxine-5-carboxylic acid

: 1181573-78-3
((1R,3S,4S)-3-aminomethyl-2-aza-bicyclo[2.2.1]hept-2-yl)-(2-methyl-5-m-tolyl-thiazol-4-yl)-methanone

: 1181571-64-1
2,3-dihydro-thieno[3,4-b][1,4]dioxine-5-carboxylic acid [(1R,3S,4S)-2-(2-methyl-5-m-tolyl-thiazole-4-carbonyl)-2-aza-bicyclo[2.2.1]hept-3-ylmethyl]-amide

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

Reference yield:

: 955961-34-9
3-chloro-2-oxo-3-m-tolylpropionic acid methylester

: 1181571-64-1
2,3-dihydro-thieno[3,4-b][1,4]dioxine-5-carboxylic acid [(1R,3S,4S)-2-(2-methyl-5-m-tolyl-thiazole-4-carbonyl)-2-aza-bicyclo[2.2.1]hept-3-ylmethyl]-amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetonitrile / Molecular sieve

2.1: water; sodium hydroxide / tetrahydrofuran

2.2: pH 3 - 4 / Cooling with ice

3.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

4.1: water; potassium carbonate / methanol / 20 h / 20 - 60 °C

5.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

With water; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1007873-99-5
2-methyl-5-(m-tolyl)thiazole-4-carboxylic acid

: 1181571-64-1
2,3-dihydro-thieno[3,4-b][1,4]dioxine-5-carboxylic acid [(1R,3S,4S)-2-(2-methyl-5-m-tolyl-thiazole-4-carbonyl)-2-aza-bicyclo[2.2.1]hept-3-ylmethyl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

2: water; potassium carbonate / methanol / 20 h / 20 - 60 °C

3: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

With water; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide;