((1R,3S,4S)-3-aminomethyl-2-aza-bicyclo[2.2.1]hept-2-yl)-(2-methyl-5-m-tolyl-thiazol-4-yl)-methanone

Base Information

Chemical Name:((1R,3S,4S)-3-aminomethyl-2-aza-bicyclo[2.2.1]hept-2-yl)-(2-methyl-5-m-tolyl-thiazol-4-yl)-methanone
CAS No.:1181573-78-3
Molecular Formula:C₁₉H₂₃N₃OS
Molecular Weight:341.477
Hs Code.:

Synonyms:((1R,3S,4S)-3-aminomethyl-2-aza-bicyclo[2.2.1]hept-2-yl)-(2-methyl-5-m-tolyl-thiazol-4-yl)-methanone

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Chemical Property of ((1R,3S,4S)-3-aminomethyl-2-aza-bicyclo[2.2.1]hept-2-yl)-(2-methyl-5-m-tolyl-thiazol-4-yl)-methanone

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Technology Process of ((1R,3S,4S)-3-aminomethyl-2-aza-bicyclo[2.2.1]hept-2-yl)-(2-methyl-5-m-tolyl-thiazol-4-yl)-methanone

There total 5 articles about ((1R,3S,4S)-3-aminomethyl-2-aza-bicyclo[2.2.1]hept-2-yl)-(2-methyl-5-m-tolyl-thiazol-4-yl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1181573-68-1
2,2,2-trifluoro-N-[(1R,3S,4S)-2-(2-methyl-5-m-tolyl-thiazole-4-carbonyl)-2-aza-bicyclo[2.2.1]hept-3-ylmethyl]-acetamide

: 1181573-78-3
((1R,3S,4S)-3-aminomethyl-2-aza-bicyclo[2.2.1]hept-2-yl)-(2-methyl-5-m-tolyl-thiazol-4-yl)-methanone

Guidance literature:: 2,2,2-trifluoro-N-[(1R,3S,4S)-2-(2-methyl-5-m-tolyl-thiazole-4-carbonyl)-2-aza-bicyclo[2.2.1]hept-3-ylmethyl]-acetamide; With water; potassium carbonate; In methanol; at 20 - 60 ℃; for 20h;

With citric acid; In water;

With sodium hydroxide; In water;

Reference yield:

: 955961-34-9
3-chloro-2-oxo-3-m-tolylpropionic acid methylester

: 1181573-78-3
((1R,3S,4S)-3-aminomethyl-2-aza-bicyclo[2.2.1]hept-2-yl)-(2-methyl-5-m-tolyl-thiazol-4-yl)-methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetonitrile / Molecular sieve

2.1: water; sodium hydroxide / tetrahydrofuran

2.2: pH 3 - 4 / Cooling with ice

3.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

4.1: water; potassium carbonate / methanol / 20 h / 20 - 60 °C

With water; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1007873-99-5
2-methyl-5-(m-tolyl)thiazole-4-carboxylic acid

: 1181573-78-3
((1R,3S,4S)-3-aminomethyl-2-aza-bicyclo[2.2.1]hept-2-yl)-(2-methyl-5-m-tolyl-thiazol-4-yl)-methanone

Guidance literature:: Multi-step reaction with 2 steps

1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

2: water; potassium carbonate / methanol / 20 h / 20 - 60 °C

With water; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide;